ArticleInternational journal of preventive medicine2026
The Effect of Synbiotic Supplementation on Malondialdehyde Levels in Adolescents Exposed to Air Pollution: A Randomized, Single-Blind, Controlled Clinical Trial.
Article in International journal of preventive medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Exposure to air pollution has been linked to elevated malondialdehyde (MDA) levels, a marker of oxidative stress, while synbiotics-by modulating the intestinal microbiota-may reduce inflammation and oxidative stress. Despite these possibilities, evidence on the effect of synbiotic supplementation in mitigating oxidative stress caused by air pollution in pediatric populations remains limited. Methods: This single-blind randomized controlled trial aimed to assess the impact of synbiotic supplementation on MDA levels among 70 healthy children and adolescents aged 10-18 years exposed to air pollution. Participants were randomly assigned to receive either synbiotics (n = 38) or omega-3 (n = 32) for 8 weeks. MDA levels were measured at baseline and after the intervention. Results: A significant reduction in MDA levels was observed within the synbiotic group (from 148.80 ± 80.72 to 51.54 ± 82.94, Conclusions: These findings suggest that synbiotics may help counteract oxidative stress induced by air pollution in children and adolescents, highlighting the need for further large-scale studies to explore their potential protective role in pediatric environmental health.
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