Evidence map›Paper›PMID 42771534›Full record

ArticleMicrobial genomics2026

Emergence of a genetically distinct cluster of influenza A(H3N2) viruses within subclade J.2.2 associated with hospitalization during the 2024-2025 season in Auvergne-Rhône-Alpes, France.

Lama Koumaty, Stéphanie Dan, Allan De Clercq, Grégory Destras, Hadrien Regue, Antoine Oblette, Adrien Le Meur, Alexandre Gaymard, Vanessa Escuret, Maude Bouscambert-Duchamp and 6 more

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Article in Microbial genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Lama KoumatyCentre National de Référence des virus des infections respiratoires, Institut des Agents Infectieux, Hospices Civils de Lyon, 69004, Lyon, France.
Stéphanie DanCentre National de Référence des virus des infections respiratoires, Institut des Agents Infectieux, Hospices Civils de Lyon, 69004, Lyon, France.
Allan De ClercqCentre National de Référence des virus des infections respiratoires, Institut des Agents Infectieux, Hospices Civils de Lyon, 69004, Lyon, France.
Grégory DestrasCentre National de Référence des virus des infections respiratoires, Institut des Agents Infectieux, Hospices Civils de Lyon, 69004, Lyon, France.
Hadrien RegueCentre National de Référence des virus des infections respiratoires, Institut des Agents Infectieux, Hospices Civils de Lyon, 69004, Lyon, France.
Antoine ObletteCentre National de Référence des virus des infections respiratoires, Institut des Agents Infectieux, Hospices Civils de Lyon, 69004, Lyon, France.
Adrien Le MeurCentre National de Référence des virus des infections respiratoires, Institut des Agents Infectieux, Hospices Civils de Lyon, 69004, Lyon, France.
Alexandre GaymardCentre National de Référence des virus des infections respiratoires, Institut des Agents Infectieux, Hospices Civils de Lyon, 69004, Lyon, France.
Vanessa EscuretCentre National de Référence des virus des infections respiratoires, Institut des Agents Infectieux, Hospices Civils de Lyon, 69004, Lyon, France.
Maude Bouscambert-DuchampCentre National de Référence des virus des infections respiratoires, Institut des Agents Infectieux, Hospices Civils de Lyon, 69004, Lyon, France.
Emmanuel ChanardService de Microbiologie, Cerballiance Auvergne-Rhône-Alpes, Lyon, France.
Margaux FabreUNILIANS-BIOGROUP, Décines-Charpieu, France.
Vincent VieillefondBPO-BIOEPINE-Biogroup, Levallois-Perret, France.
Benoit VisseauxLaboratoire Cerba, Département d'infectiologie, Laboratoire Cerba, Cerba Healthcare, Frépillon, France.
Antonin BalCentre National de Référence des virus des infections respiratoires, Institut des Agents Infectieux, Hospices Civils de Lyon, 69004, Lyon, France.
Laurence JossetCentre National de Référence des virus des infections respiratoires, Institut des Agents Infectieux, Hospices Civils de Lyon, 69004, Lyon, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the 2024-2025 influenza season in Auvergne-Rhône-Alpes, France, a genetically distinct cluster of A(H3N2) viruses within subclade J.2.2 was found to be significantly overrepresented in hospitalized patients compared with community patients. Circulating mainly in November and December 2024, this genetically distinct cluster harboured HA1:G62R and S145N mutations, both linked to immune escape, as well as P239Q, located near key antigenic sites and warranting further investigation. The findings highlight the importance of monitoring influenza genome diversity in both hospital and community settings to identify emerging genetically distinct clusters with potential for increased severity.

Indexed as

Influenza A Virus, H3N2 SubtypeInfluenza, HumanFranceGenome, ViralHemagglutinin Glycoproteins, Influenza VirusHospitalizationHumansMutationPhylogenySeasonsWhole Genome SequencingHemagglutinin Glycoproteins, Influenza Virusgenomic surveillanceinfluenzapublic healthseveritywhole-genome sequencing

Identifiers

PMID42771534
PMCPMC13597097

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.