Tunable and self-reporting esterase-activated cyanide prodrugs exert cytoprotective effects.

Xidan Tong, Wen Peng, Jinkang Feng, Shengping Huang, Jianru Liu, Wei Li, Jiaxuan Chen, Weiwei Guo, Yueqin Zheng

Abstract read

In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xidan Tong *State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Drug Discovery, China Pharmaceutical University, Nanjing, P. R. China.

Wen Peng *Key Laboratory of Ethnic Medicine Resource Chemistry, Ministry of Education, Yunnan Minzu University, Kunming, Yunnan, P. R. China.

Jinkang Feng *State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Drug Discovery, China Pharmaceutical University, Nanjing, P. R. China.

Shengping HuangState Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Drug Discovery, China Pharmaceutical University, Nanjing, P. R. China.

Jianru LiuState Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Drug Discovery, China Pharmaceutical University, Nanjing, P. R. China.

Wei LiState Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Drug Discovery, China Pharmaceutical University, Nanjing, P. R. China.

Jiaxuan ChenState Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Drug Discovery, China Pharmaceutical University, Nanjing, P. R. China.

Weiwei GuoDepartment of Chemistry, China Pharmaceutical University, Nanjing, P. R. China.

Yueqin ZhengState Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Drug Discovery, China Pharmaceutical University, Nanjing, P. R. China. yzheng@cpu.edu.cn.ORCID 0009-0004-8912-6044

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrogen cyanide (HCN) is increasingly recognized as a mammalian gasotransmitter with biphasic biological effects, but its study is limited by the lack of controllable delivery tools. Here we report esterase-activated, self-reporting cyanide donors with tunable release kinetics and fluorogenic readout. Upon esterase activation, the donors synchronously release cyanide and regenerate an ICT-based fluorophore. Steric modulation at the cyanohydrin α-carbon controls the release rate over one order of magnitude (k

Indexed as

CyanidesCytoprotectionEsterasesHydrogen CyanideProdrugsAnimalsHumansLipid PeroxidationMiceCyanidesEsterasesHydrogen CyanideProdrugs

Identifiers

PMID42773121

DOI10.1038/s41467-026-76960-z

PMCPMC13598110

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.