Evidence map›Paper›PMID 42773180›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Measuring in-vivo tau pathology in the basal forebrain with PET imaging.

Theresa M Harrison, Trevor A Chadwick, Michel J Grothe, Tyler Ward, Suzanne L Baker, Susan M Landau, William J Jagust, Alzheimer’s Disease Neuroimaging Initiative

Abstract read
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In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Theresa M HarrisonDepartment of Neuroscience, University of California Berkeley, Berkeley, CA, USA. tessaharrison@berkeley.edu.ORCID http://orcid.org/0000-0002-2036-3496
Trevor A ChadwickDepartment of Neuroscience, University of California Berkeley, Berkeley, CA, USA.
Michel J GrotheReina Sofia Alzheimer Centre, CIEN Foundation, ISCIII, Madrid, Spain.
Tyler WardDepartment of Neuroscience, University of California Berkeley, Berkeley, CA, USA.
Suzanne L BakerLawrence Berkeley National Laboratory, Berkeley, CA, USA.
Susan M LandauDepartment of Neuroscience, University of California Berkeley, Berkeley, CA, USA.
William J JagustDepartment of Neuroscience, University of California Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-4458-113X
Alzheimer’s Disease Neuroimaging Initiative

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MICHAEL W WEINER · 2016 to 2026
$226.7M
US POINTER Neuroimaging Ancillary StudyR01AG062689 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI LANDAU, SUSAN M · 2019 to 2025
$47.3M
Neural and Biochemical Mechanisms of Cognitive AgingR01AG034570 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI William J. Jagust · 2009 to 2026
$12.0M
Linking basal forebrain and entorhinal cortex vulnerability to preclinical Alzheimer's diseaseK01AG078443 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI Theresa M. Harrison · 2022 to 2026
$656k
U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) K01 AG078443U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01 AG034570U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01 AG062689U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) U19 AG024904
6 · The paper itself

Abstract

The basal forebrain (BF) is a site of early tau pathology deposition, and BF cholinergic neurons selectively degenerate in patients with Alzheimer's disease (AD). PET imaging of AD pathology has helped to establish the relationships between early tau in the medial temporal lobe (MTL), amyloid (Aβ) pathology, brain structure and cognition, but it is not clear if PET imaging can be used to similarly characterize early tau pathology in the BF. Here we aim to test the feasibility of measuring tau pathology in the BF in unimpaired older adults with two PET tracers, [

Identifiers

PMID42773180

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.