Evidence map›Paper›PMID 42773283›Full record

ArticleNature cardiovascular research2026

Proteome-wide genetic analyses identify ASGR1 as a potential biomarker linking smoking with ischemic heart disease.

Alexander C Tinworth, Pang Yao, Andri Iona, Alfred Pozarickij, Adam Von Ende, Iona Y Millwood, Robin G Walters, Robert Clarke, Fiona Bragg, Zhengming Chen

Abstract read
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In one paragraph

Article in Nature cardiovascular research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexander C TinworthClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Pang YaoClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Andri IonaClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Alfred PozarickijClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Adam Von EndeClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Iona Y MillwoodClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-0807-0682
Robin G WaltersClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-9179-0321
Robert ClarkeClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-9802-8241
Fiona BraggClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK. fiona.bragg@ndph.ox.ac.uk.ORCID http://orcid.org/0000-0002-9181-6886
Zhengming ChenClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK. zhengming.chen@ndph.ox.ac.uk.ORCID http://orcid.org/0000-0001-6423-105X

Funding

British Heart Foundation (BHF) RE/18/3/34214
6 · The paper itself

Abstract

Tobacco smoking increases the risk of multiple diseases, but the biological mechanisms involved remain incompletely understood. Here we characterize smoking-related protein profiles to identify potentially causal biomarkers mediating smoking's effects. In European-ancestry populations, genetically predicted smoking exposures were significantly associated with levels of 93 (total: 2,922) proteins, including higher levels of asialoglycoprotein receptor 1 (ASGR1). The positive association of ASGR1 levels with ischemic heart disease (IHD) was supported by colocalization (posterior probability of hypothesis 4 = 0.91), and was estimated to explain 6.35% (95% confidence interval 2.61-10.09%, P = 8.77 × 10

Identifiers

PMID42773283

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.