Evidence map›Paper›PMID 42773704›Full record

ArticleChemistry & biodiversity2026

Exploring the Multitarget Pharmacological Potential of Halogeton sativus Secondary Metabolites: An Integrated Experimental and Computational Approach.

Abd Elbasset Tamersit, Soumia Mouffouk, Chaima Mouffouk, Faizul Azam, Rayan A Mulla, Najeh Kharbatia, Mariusz Jaremko, Abdul-Hamid Emwas, Nourhene Hamdaoui, Saoudi Mongi and 3 more

Abstract read
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Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Abd Elbasset TamersitLaboratory of Chemistry and Environmental Chemistry (LCCE), Department of Chemistry, Faculty of Matter Sciences, University of Batna 1, Batna, Algeria.ORCID https://orcid.org/0009-0009-6742-5728
Soumia MouffoukLaboratory of Chemistry and Environmental Chemistry (LCCE), Department of Chemistry, Faculty of Matter Sciences, University of Batna 1, Batna, Algeria.ORCID https://orcid.org/0000-0001-7704-4093
Chaima MouffoukLaboratory of Chemistry and Environmental Chemistry (LCCE), Department of Chemistry, Faculty of Matter Sciences, University of Batna 1, Batna, Algeria.ORCID https://orcid.org/0000-0003-1436-8685
Faizul AzamDepartment of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah, Saudi Arabia.ORCID https://orcid.org/0000-0002-2927-8167
Rayan A MullaBiomedical Sciences Division (BioMed), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.ORCID https://orcid.org/0000-0002-7426-1401
Najeh KharbatiaWater Desalination and Reuse Platform, KAUST, Thuwal, Saudi Arabia.ORCID https://orcid.org/0000-0003-1424-6282
Mariusz JaremkoThe Golden Ratio Institute, Riyadh, Saudi Arabia.
Abdul-Hamid EmwasCore Lab of NMR, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.ORCID https://orcid.org/0000-0002-9231-3850
Nourhene HamdaouiLaboratory of Biomathematics (LR22ES01), Faculty of Sciences of Sfax, University of Sfax, Sfax, Tunisia.
Saoudi MongiLaboratory of Biomathematics (LR22ES01), Faculty of Sciences of Sfax, University of Sfax, Sfax, Tunisia.
Sara MouffoukLaboratory of Cellular and Molecular Physio-Toxicology-Pathology and Biomolecules (LPTPCMB), Department of Biology of Organisms, Faculty of Natural and Life Sciences, University of Batna 2, Batna, Algeria.
Waffa BouafiaLaboratory of Chemistry and Environmental Chemistry (LCCE), Department of Chemistry, Faculty of Matter Sciences, University of Batna 1, Batna, Algeria.ORCID https://orcid.org/0000-0002-3265-7280
Hamada HabaLaboratory of Chemistry and Environmental Chemistry (LCCE), Department of Chemistry, Faculty of Matter Sciences, University of Batna 1, Batna, Algeria.ORCID https://orcid.org/0000-0002-7979-5007

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study offers an in-depth analysis of Halogeton sativus, traditionally consumed in the Mediterranean region. Phytochemical investigation of crude extracts allowed the isolation and spectroscopic identification of 15 secondary metabolites. α-Amylase inhibitory and anti-inflammatory activities were determined via the caraway iodine method, heat-induced lysis, and denaturation inhibition assays, respectively. The antimicrobial activity was tested using a disc diffusion method, and the antioxidant effects were assessed by six methods. The ethyl acetate extract (HS-EtOAc) showed a stronger α-amylase inhibitory effect (IC

Indexed as

alpha-AmylasesAnti-Bacterial AgentsAntioxidantsEnzyme InhibitorsPlant ExtractsAnimalsHumansInterleukin-1betaMicrobial Sensitivity TestsMolecular Docking SimulationMolecular StructureSecondary MetabolismStructure-Activity Relationshipalpha-AmylasesAnti-Bacterial AgentsAntioxidantsEnzyme InhibitorsInterleukin-1betaPlant ExtractsADMETbiological activitiesdockingdynamicsHalogeton sativusphytochemicals

Identifiers

PMID42773704
PMCPMC13598349

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.