Evidence map›Paper›PMID 42774019›Full record

ArticleMolecular vision2026

A mutation in

Gizem Ulker-Yilmazer, Dogan Can Kirman, Tian Yu, Emily R Turpin, Sangita Shrestha, Seher Yuksel, Yu-Guang He, Sara Ludwig, Ashwani Kumar, Chao Xing and 4 more

Abstract read
In one paragraph

Article in Molecular vision, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gizem Ulker-YilmazerDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX.
Dogan Can KirmanDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX.
Tian YuDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX.
Emily R TurpinDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX.
Sangita ShresthaDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX.
Seher YukselDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX.
Yu-Guang HeDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX.
Sara LudwigCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX.
Ashwani KumarMcDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX.
Chao XingMcDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX.
Eva M Y MorescoCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX.
Bruce A BeutlerCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX.
Bogale AredoDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX.
Rafael L Ufret-VincentyDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX.

Funding

Automated Forward Genetic Analysis of Adaptive ImmunityR01AI125581 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI BRUCE A BEUTLER · 2016 to 2026
$19.5M
Stem Cell, Organoid and Cell Phenotyping ModuleP30EY030413 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI W MATTHEW PETROLL · 2019 to 2026
$5.9M
Exploring Mechanisms in Retinal Development/Homeostasis, Retinal Immune Surveillance and Diabetic Retinopathy Using Forward GeneticsR01EY033181 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI UFRET-VINCENTY, RAFAEL · 2021 to 2025
$2.2M
Using Forward Genetics to Explore the Genetics and Mechanisms of Early Onset GlaucomaR21EY036238 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI UFRET-VINCENTY, RAFAEL · 2024 to 2025
$451k
NEI NIH HHS P30 EY030413NEI NIH HHS R01 EY033181NEI NIH HHS R21 EY036238NIAID NIH HHS R01 AI125581
6 · The paper itself

Abstract

Purpose: Both photoreceptors and the retinal pigment epithelium (RPE) are highly metabolically active cell types that require extensive molecular transport and adequate energy production to maintain their function. We tested the hypothesis that cargo adaptor protein Bicdl1 has a non-redundant role in retinal health. Methods: Using an unbiased forward genetics approach, we identified an association between outer retinal thinning and a point mutation in Results: Analysis of OCT images and histology sections demonstrated a mild decrease in outer retinal thickness and rod outer segment thickness. We found an increased number of fundus spots in retinal photographs and an increased number of Iba1 Conclusion: Despite the expression of many cargo adaptor proteins and dynein activators in the retina, we identified a novel non-redundant role of

Indexed as

Adaptor Proteins, Signal TransducingPoint MutationRetinaRetinal DegenerationRetinal Pigment EpitheliumAnimalsDisease Models, AnimalElectroretinographyEye ProteinsMiceMice, Inbred C57BLMitochondriaMutationPhenotypeTomography, Optical CoherenceAdaptor Proteins, Signal TransducingEye Proteins

Identifiers

PMID42774019
PMCPMC13568186

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.