ArticleFrontiers in immunology2026
Dynamic orchestration of structural and immune cells in acute
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Methods: We performed time-resolved single-cell RNA sequencing (scRNA-seq) on murine lungs across five timepoints (0-96 h post-infection) and integrated these data with spatial transcriptomics (10x Visium) performed on matched tissue sections at key timepoints (0, 24, and 96 h), profiling a total of 41,452 high-quality cells. Results: We identified four neutrophil subsets, with the N3 population exhibiting potent antimicrobial activity. We traced the emergence of inflammatory fibroblasts during acute infection to Col13a1 Conclusion: Our integrative time-resolved spatial transcriptomic atlas elucidates how structural and immune cells orchestrate the balance between bacterial clearance and tissue repair, highlighting novel targets for host-directed therapies in
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