SynthesisFrontiers in public health2026
Orally transmitted Chagas disease outbreaks in Latin America: a comprehensive systematic review and public health implications.
Synthesis in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Food-borne Chagas disease is an emerging public health concern in South America, yet key aspects of its epidemiology and clinical impact remain poorly characterized. This systematic review aimed to systematically synthesize the available evidence on food-borne Chagas disease outbreaks in order to characterize their epidemiological, clinical, laboratory, treatment, and follow-up features, and to identify major knowledge gaps. Methods: A systematic review of food-borne Chagas disease outbreaks reported between 1965 and 2024 was conducted following PRISMA-2020 guidelines (PROSPERO-CRD42024542461). Independent reviewers screened studies and extracted data on epidemiology, food sources, diagnostics, clinical presentation, treatment, follow-up, seasonality, vectors, and parasite lineages. Results: Among 835 records identified, 111 studies met the inclusion criteria, describing 114 outbreaks in six countries, comprising 1,293 cases and 77 deaths (case fatality rate: 5.95%). Reported outbreaks increased 7.1-fold during the second half of the study period. Food sources were epidemiologically identified in only 12 outbreaks, with microbiological confirmation achieved in just one of them. In a further 82 outbreaks, the implicated food vehicle was classified as suspected based on epidemiological evidence, while no food source was identified in the remaining 20 outbreaks. Açaí was the most frequently implicated food in Brazil (32/64 outbreaks), whereas fruit-based beverages predominated elsewhere. Outbreaks clustered in Amazonian and tropical regions and occurred mainly during warm and rainy seasons, with predominance of sylvatic TcI/TcIV lineages and frequent involvement of Conclusion: Food-borne Chagas disease remains an important mode of Systematic review registration: PROSPERO 2024 CRD42024542461. Available online at: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024542461.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.