Lower lipoprotein(a) levels in patients with acute lacunar infarction.

Xiangliang Chen, Nihong Chen, Lin Zhu, Qing Huang, Fuping Jiang

Abstract read

In one paragraph

Article in IBRO neuroscience reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

5 authors.

Xiangliang ChenDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.

Nihong ChenDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.

Lin ZhuDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.

Qing HuangDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.

Fuping JiangDepartment of Geriatrics, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Serum lipoprotein(a) [Lp(a)] is a well-established risk factor for atherosclerotic cardiovascular diseases. However, studies on the correlation between Lp(a) and acute lacunar infarction (ALI) remain inconclusive. We conducted a case-control study to investigate the association between serum Lp(a) levels and ALI in a Chinese population. Methods: We consecutively enrolled 989 patients with ALI (719 males, 270 females; mean age 64.63 ± 11.97 years) and an equal number of sex-matched controls with available brain MRI from the Departments of Neurology and Geriatrics. Univariate and multivariable binary logistic regression analyses were used to examine the relationships between Lp(a) concentrations and the presence of ALI. Results: Serum Lp(a) levels were significantly lower in the ALI group compared to controls. Multivariable logistic regression revealed an independent inverse association between Lp(a) levels and the presence of ALI (odds ratio [OR], 0.76; 95% confidence interval [CI], 0.66-0.87; Conclusions: This study demonstrates that lower serum Lp(a) levels are independently associated with the presence of ALI. The clinical implications and underlying biological mechanisms of this observation warrant further investigation.

Indexed as

Acute lacunar infarctionCerebral small vessel diseaseLipoprotein(a)

Identifiers

PMID42774994

DOI10.1016/j.ibneur.2026.09.001

PMCPMC13594962

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.