Evidence map›Paper›PMID 42775636›Full record

ArticleeLife2026

Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep.

Lin Yan, Litao Wu, Timothy D Wiggin, Xiaojuan Su, Wei Yan, Hailiang Li, Lei Li, Zhonghua Lu, Fang Guo, Zhiqiang Meng and 4 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Lin YanDepartment of Anesthesiology, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, China.ORCID https://orcid.org/0000-0001-8186-9864
Litao WuShenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Timothy D WigginDepartment of Biology, Volen National Center for Complex Systems, Brandeis University, Waltham, United States.
Xiaojuan SuShenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Wei YanShenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Hailiang LiSchool of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China.ORCID https://orcid.org/0009-0008-1458-8577
Lei LiShenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Zhonghua LuShenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Fang GuoSchool of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China.ORCID https://orcid.org/0000-0002-0433-9808
Zhiqiang MengShenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Yuantao LiDepartment of Anesthesiology, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, China.
Fan LiDepartment of Pathophysiology, Shantou University Medical College, Shantou, China.ORCID https://orcid.org/0000-0002-7566-2151
Leslie C GriffithDepartment of Biology, Volen National Center for Complex Systems, Brandeis University, Waltham, United States.ORCID https://orcid.org/0000-0003-3164-9876
Chang LiuShenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.ORCID https://orcid.org/0000-0001-6755-4831

Funding

Regulation of Intrinsic Plasticity in Neural CircuitsR01MH067284 · NIMH · BRANDEIS UNIVERSITY · PI GRIFFITH, LESLIE C · 2003 to 2025
$8.8M
CAS Key Laboratory of Brain Connectome and Manipulation 2019DP173024Guangdong Basic and Applied Basic Research Foundation 2024A151501150Guangdong Basic and Applied Basic Research Foundation 2025A1515011127National Natural Science Foundation of China 32071009National Natural Science Foundation of China 32371063National Natural Science Foundation of China 82171430National Natural Science Foundation of China 82341248NIH HHS R01MH67284NIMH NIH HHS R01 MH067284Shenzhen Science and Technology Program KQTD20221101093608028
6 · The paper itself

Abstract

Sleep disturbances are associated with poor long-term memory (LTM) formation, yet the underlying cell types and neural circuits involved have not been fully decoded. Dopamine neurons (DANs) are involved in memory processing at multiple stages. Here, using both male and female flies,

Indexed as

Dopaminergic NeuronsDrosophila melanogasterMemory ConsolidationMemory, Long-TermSleepAnimalsDrosophila ProteinsFemaleMaleReceptors, DopamineReceptors, Dopamine D1Dop1R1 protein, DrosophilaDrosophila ProteinsReceptors, DopamineReceptors, Dopamine D1D. melanogasterdopaminedopamine receptorinternal statememory consolidationneural circuitneurosciencesleep

Identifiers

PMID42775636
PMCPMC13600697

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.