ArticleGeroScience2026
Age-Related Changes in Spontaneous Brain Dynamics Revealed by Resting-State Magnetoencephalography.
Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
Abstract
Spontaneous neuronal oscillations support large-scale brain communication and are sensitive to adult aging, yet how their moment-to-moment dynamics change across the adult lifespan and relate to cognition remains unclear. Here, we used resting-state magnetoencephalography (MEG) and time-delay embedded hidden Markov modelling to characterize transient oscillatory brain states in 617 healthy adults aged 18-88 years. Aging was associated with a frequency- and region-specific reorganization of spontaneous activity, characterized by increased anterior delta/theta power and reduced posterior alpha and sensorimotor beta power. At the network level, older adults showed lower fractional occupancy of a posterior state dominated by alpha activity. Within this posterior state, stronger alpha-band connectivity was modestly associated with better Addenbrooke's Cognitive Examination-Revised (ACE-R) performance, suggesting that posterior alpha coupling is related to individual differences in global cognitive performance as captured by this measure. Together, these findings reveal subtle age-related differences in spontaneous brain dynamics across the adult lifespan, including a posterior-to-anterior redistribution of state occupancy. Rather than establishing a clinical biomarker or a general marker of cognitive aging, the present results identify posterior alpha connectivity as a behaviorally relevant resting-state MEG feature that warrants further validation in longitudinal and multimodal studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.