ArticleVirulence2026
Comparative pathogenicity study of monkeypox virus Clade Ib and Clade IIb in a rabbit model.
Article in Virulence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mpox has emerged as a significant public health concern, spreading across continents with the emergence of new variants. Clade IIb, from the recent global outbreak, and the newly identified Clade Ib have shown changes in transmission dynamics and possibly in severity. We developed a New Zealand White rabbit model of Mpox by using a combination of intradermal and intravenous routes of administration. Following infection, the rabbits developed erythematous papular lesions on the skin, which progressed to crust and scab formation by the second week, ultimately leading to healing and seroconversion. Infection with the Clade Ib and IIb.A.2.1 lineages revealed that both Monkeypox virus (MPXV) variants caused skin and testicular lesions, as well as viral excretion from the nasal cavity, skin, and testicular tissue. However, there were no significant differences in disease severity between the two variants. These findings suggest that this rabbit model could be useful for evaluating countermeasures against MPXV.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.