Evidence map›Paper›PMID 42778596›Full record

ArticleNature2026

Hepatocytes promote liver metastasis of pancreatic cancer by providing serine.

Koelina Ganguly, Keisuke Yamamoto, Jason Rodencal, Joel Encarnacion-Rosado, Albert S W Sohn, Douglas E Biancur, Elaine Y Lin, Ruohong Wang, Carolina Alcantara Hirsch, Anthony Sorrentino and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Koelina Ganguly *Department of Radiation Oncology, New York University Grossman School of Medicine, New York, NY, USA.
Keisuke Yamamoto *Department of Radiation Oncology, New York University Grossman School of Medicine, New York, NY, USA. kyamamoto-tky@g.ecc.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0002-6323-9540
Jason Rodencal *Department of Radiation Oncology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-5637-611X
Joel Encarnacion-RosadoDepartment of Radiation Oncology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-0440-4278
Albert S W SohnDepartment of Radiation Oncology, New York University Grossman School of Medicine, New York, NY, USA.
Douglas E BiancurDepartment of Radiation Oncology, New York University Grossman School of Medicine, New York, NY, USA.
Elaine Y LinDepartment of Radiation Oncology, New York University Grossman School of Medicine, New York, NY, USA.
Ruohong WangDepartment of Radiation Oncology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0009-0003-9456-6514
Carolina Alcantara HirschDepartment of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-2193-362X
Anthony SorrentinoDepartment of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.
Elshaddai Z WhiteDepartment of Radiation Oncology, New York University Grossman School of Medicine, New York, NY, USA.
Paul M GrandgenettEppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
Michael A HollingsworthEppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.ORCID http://orcid.org/0000-0002-5255-8888
Miwako KakiuchiDepartment of Preventive Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Richard PossematoDepartment of Radiation Oncology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-2401-0030
Dafna Bar-SagiDepartment of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.
Mitsuhiro FujishiroDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Alec C KimmelmanDepartment of Radiation Oncology, New York University Grossman School of Medicine, New York, NY, USA. alec.kimmelman@nyulangone.org.ORCID http://orcid.org/0009-0002-9465-8411

Funding

Critical Resources Provided by UNMC Rapid Autopsy Program (RAP) Biorepository Stimulate Cancer ResearchR50CA211462 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Paul M Grandgenett · 2016 to 2026
$1.4M
NCI NIH HHS R50 CA211462
6 · The paper itself

Abstract

The liver is the primary site of metastasis in pancreatic ductal adenocarcinoma (PDAC), and liver metastases are a major cause of mortality

Identifiers

PMID42778596

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.