Scaffold hopping of furans into 3-cyanopyridines.

Prakash Kafle, Shuhei Yasuda, Deacon Herndon, Daniel Nilson, Rylan C Fox, Novruz G Akhmedov, Indrajeet Sharma

Abstract read

In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Prakash Kafle *Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA.ORCID http://orcid.org/0009-0006-2069-7011

Shuhei Yasuda *Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA.ORCID http://orcid.org/0009-0009-6835-6429

Deacon HerndonDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA.

Daniel NilsonDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA.ORCID http://orcid.org/0009-0002-5013-4413

Rylan C FoxDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA.ORCID http://orcid.org/0009-0007-2880-6187

Novruz G AkhmedovDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA.

Indrajeet SharmaDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA. isharma@ou.edu.ORCID http://orcid.org/0000-0002-0707-0621

Funding

ACS | American Chemical Society Petroleum Research Fund (ACS Petroleum Research Fund) 69051-ND1

6 · The paper itself

Abstract

Furans are economically accessible bulk chemicals largely derived from lignocellulosic biomass. Although the furan motif is widely found in natural products, it remains underrepresented in FDA-approved therapeutics owing to its metabolic instability. This gap underscores the need for strategies that diversify and functionalize furan scaffolds for drug discovery. Here, we report a scaffold-hopping strategy in which the cyano-sulfenylcarbene selectively cleaves the furan core, generating dienone intermediates bearing an intrinsic thioaryl leaving group. A subsequent reaction with a nitrogen source restores aromaticity and yields pyridines, a privileged and pharmaceutically indispensable heterocycle. This metal-free process exhibits broad functional-group tolerance, enables

Identifiers

PMID42778615

DOI10.1038/s41467-026-77185-w

PMCPMC13601626

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.