SynthesisTechniques in coloproctology2026
Indocyanine green fluorescence angiography for prevention of anastomotic leak in colorectal surgery: a graded systematic review and meta-analysis with trial sequential analysis of randomized controlled trials.
Synthesis in Techniques in coloproctology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnastomotic leak (AL) is a major driver of morbidity after colorectal resection. Indocyanine-green fluorescence angiography (ICG-FA) provides real-time intraoperative perfusion assessment, but its impact across randomized trials remains debated. This review aims to evaluate the efficacy and safety of ICG-FA compared with conventional intraoperative assessment in preventing AL in colorectal surgery.
methodsA systematic review and a meta-analysis was conducted in accordance with the PRISMA guidelines, including RCTs comparing ICG-FA with conventional assessment. The primary outcome was overall AL; secondary outcomes included leak grade, anatomic location, operative metrics, and change in surgical plan (CISP). Pooled risk ratios (RR) or mean differences (MD) with 95% confidence intervals (CI) were calculated using random- or fixed-effects models. Trial sequential analysis (TSA) was used to evaluate evidence sufficiency.
resultsEight RCTs (n = 4712) met the inclusion criteria. ICG-FA reduced overall AL versus control (risk ratio [RR] 0.68, 95% CI 0.58-0.81; I
conclusionsHigh-certainty evidence demonstrates that ICG-FA reduces overall and low-grade AL, principally in left-sided resections, without prolonging operative time. ICG-FA should be considered an evidence-based adjunct to optimize perfusion assessment in colorectal surgery. REGISTRATION: PROSPERO CRD420251139372.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.