ArticleArteriosclerosis, thrombosis, and vascular biology2026
Air Pollution Triggers Metabolomic Signature of Mitochondrial Dysfunction in Mice and Humans: Implications for Cardiovascular Disease Development.
Yan Lin, Xinghua Qiu, Rajat Gupta, Gajalakshmi Ramanathan, Xinchen Lu, Fen Yin, Oliver Fiehn, Junfeng Jim Zhang, Joel D Kaufman, Yifang Zhu and 2 more
Abstract read
In one paragraphArticle in Arteriosclerosis, thrombosis, and vascular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Yan LinNicholas School of the Environment and Duke Global Health Institute, Duke University, Durham, NC (Y.L., J.J.Z.).
Xinghua QiuCollege of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing, China (X.Q., X.L.).ORCID 0000-0001-9874-8030 Rajat GuptaDepartment of Medicine, David Geffen School of Medicine (R.G., G.R., F.Y., J.A.A.), University of California, Los Angeles.ORCID 0000-0003-2887-1935 Gajalakshmi RamanathanDepartment of Medicine, David Geffen School of Medicine (R.G., G.R., F.Y., J.A.A.), University of California, Los Angeles.
Xinchen LuCollege of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing, China (X.Q., X.L.).
Fen YinDepartment of Medicine, David Geffen School of Medicine (R.G., G.R., F.Y., J.A.A.), University of California, Los Angeles.
Junfeng Jim ZhangNicholas School of the Environment and Duke Global Health Institute, Duke University, Durham, NC (Y.L., J.J.Z.).ORCID 0000-0003-3759-6672 Yifang ZhuDepartment of Environmental Health Sciences, Jonathan and Karin Fielding School of Public Health (Y.Z., J.A.A.), University of California, Los Angeles.ORCID 0000-0002-0591-3322 Michael RosenfeldDepartment of Environmental and Occupational Health Sciences (J.D.K., M.R.).
Jesus A AraujoDepartment of Medicine, David Geffen School of Medicine (R.G., G.R., F.Y., J.A.A.), University of California, Los Angeles.ORCID 0000-0001-8279-8922 Funding
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Sheela Sathyanarayana · 1995 to 2026
$42.5MProject 5: ROS, Glutathione and Vascular Response to Diesel ExhaustP50ES015915 · NIEHS · UNIVERSITY OF WASHINGTON · PI KAUFMAN, JOEL DANIEL · 2008 to 2012
$11.8MDissecting the Role of Arachidonic Acid Metabolic Pathways Involved in Resolution Versus Progression of PM-Induced Cardiometabolic ToxicityR01ES033703 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jesus Antonio Araujo · 2022 to 2026
$3.3MEffects of particulate air pollution on HDL function and atherosclerosisR01ES016959 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARAUJO, JESUS ANTONIO · 2009 to 2013
$2.4MRole of Intestinal Microbiota in Dyslipidemia and Atherosclerosis Induced by Ambient Ultrafine ParticlesR01ES029395 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARAUJO, JESUS ANTONIO, HSIAI, TZUNG K · 2018 to 2022
$2.2MInterplay Between Macrophages, Lipid Oxidation and the Nrf2/HO-1 Axis in the Cardiometabolic Toxicity Induced by Ultrafine ParticlesR01ES032806 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARAUJO, JESUS ANTONIO · 2021 to 2025
$2.0MAir Pollution and Cardiovascular Diseases: Identification of Novel BiomarkersR21ES024560 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARAUJO, JESUS ANTONIO, ZHU, YIFANG · 2015 to 2016
$424kNIEHS NIH HHS P30 ES007033NIEHS NIH HHS P50 ES015915NIEHS NIH HHS R01 ES016959NIEHS NIH HHS R01 ES029395NIEHS NIH HHS R01 ES032806NIEHS NIH HHS R01 ES033703NIEHS NIH HHS R21 ES024560
6 · The paper itselfAbstract
backgroundPrevious animal studies found that subchronic exposure to diesel exhaust induces hyperlipidemia, accompanied by upregulation of 12-LOX (lipoxygenase) and 15-LOX pathways and hepatic mitochondrial dysfunction. However, the human relevance of these findings has not been established.
methodsWe studied ApoE
resultsEnrichment analysis of overlapping metabolites detected in both mice and humans indicates that air pollution induced metabolic alterations in (1) dicarboxylic acids, (2) acylcarnitines, (3) tryptophan, (4) pyrimidine, and (5) lysine pathways. Although the metabolomic signatures of tryptophan, pyrimidine, and lysine metabolites differed between mice and humans, we observed consistent increases in long-chain dicarboxylic acids and medium-to-long-chain acylcarnitines, likely due to mitochondrial dysfunction as evidenced by impaired mitochondrial respiration in a Seahorse assay on livers from the same mice. In the human study, the changes in dicarboxylic acids and acylcarnitines were significantly associated with increased lipid peroxidation products from 12- and 15-LOX pathways and exposure biomarkers for polycyclic aromatic hydrocarbons.
conclusionsWe provide real-world human evidence supporting that mitochondrial dysfunction and impaired fatty acid oxidation are plausible mechanisms mediating the adverse early metabolic effects of air pollution.
Indexed as
air pollutionfatty acidslipid metabolismmetabolomicsmitochondria
Identifiers
PMID42779538
PMCPMC13614516
What Socratic holds
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