ArticleArteriosclerosis, thrombosis, and vascular biology2026
Associations of Brain Structure and Neuropsychological Function With Artificial Intelligence Estimates of Biological Vascular Age.
Leroy L Cooper, Ayantika Banerjee, Alexa S Beiser, Sokratis Charisis, David J Hamel-Sellman, Timothy J Korzinski, Emelia J Benjamin, Naomi M Hamburg, Ramachandran S Vasan, Sudha Seshadri and 1 more
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In one paragraphArticle in Arteriosclerosis, thrombosis, and vascular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Ayantika BanerjeeDepartment of Biostatistics (A.B., A.S.B.), Boston University School of Public Health, MA.ORCID 0009-0001-6779-5106 Alexa S BeiserDepartment of Biostatistics (A.B., A.S.B.), Boston University School of Public Health, MA.ORCID 0000-0001-8551-7778 Sokratis CharisisGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX (S.C., S.S.).ORCID 0000-0001-6578-393X Emelia J BenjaminDepartment of Epidemiology (E.J.B.), Boston University School of Public Health, MA.ORCID 0000-0003-4076-2336 Naomi M HamburgWhitaker Cardiovascular Institute (E.J.B., N.M.H.), Boston University Chobanian & Avedisian School of Medicine, MA.ORCID 0000-0001-5504-5589 Ramachandran S VasanBoston University and NHLBI's Framingham Study, MA (A.B., A.S.B., E.J.B., R.S.V., S.S.).ORCID 0000-0001-7357-5970 Sudha SeshadriBoston University and NHLBI's Framingham Study, MA (A.B., A.S.B., E.J.B., R.S.V., S.S.).ORCID 0000-0001-6135-2622 Funding
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN · 2019 to 2024
$29.8MPRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9MIDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6MConProject-006U54HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BHATNAGAR, ARUNI, ROBERTSON, ROSE MARIE · 2018 to 2022
$18.8MMRI, Genetics &Cognitive Precursors of AD &DementiaR01AG016495 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 1999 to 2016
$12.5MTemporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3MCardiac microstructure and the immune-inflammatory response to SARS-CoV-2R01HL131532 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHENG, SUSAN, LI, DEBIAO · 2016 to 2025
$6.6MClinical and Genetic Correlates of Vascular Function in African Americans: JHSR01HL104184 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI FOX, ERVIN R · 2011 to 2017
$4.5MFramingham: Inflammation, Genes &Cardiovascular DiseaseR01HL076784 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2004 to 2008
$3.9MVentricular Vascular Coupling: Correlates and PrognosisR01HL080124 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2005 to 2009
$3.4MMediators of Systemic Inflammation and Heart Failure Risk in the CommunityR01HL143227 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHENG, SUSAN · 2019 to 2022
$3.3MCAPSITE: Community Assessment of Pain and Sensitization in the ElderlyR01AG066010 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., EDWARDS, ROBERT R · 2020 to 2025
$3.3MNHLBI NIH HHS 75N92019D00031NHLBI NIH HHS K01 HL161494NHLBI NIH HHS K24 HL004334NHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL070100NHLBI NIH HHS R01 HL071039NHLBI NIH HHS R01 HL076784NHLBI NIH HHS R01 HL077447NHLBI NIH HHS R01 HL080124NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL093328NHLBI NIH HHS R01 HL094898NHLBI NIH HHS R01 HL104184NHLBI NIH HHS R01 HL107385NHLBI NIH HHS R01 HL115391NHLBI NIH HHS R01 HL126136NHLBI NIH HHS R01 HL128914NHLBI NIH HHS R01 HL131532NHLBI NIH HHS R01 HL142983NHLBI NIH HHS R01 HL143227NHLBI NIH HHS R01 HL168889NHLBI NIH HHS U54 HL120163NIA NIH HHS R01 AG016495NIA NIH HHS R01 AG028321NIA NIH HHS R01 AG049607NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG066010NIA NIH HHS RF1 AG079390NIDDK NIH HHS R01 DK080739NINDS NIH HHS R01 NS017950
6 · The paper itselfAbstract
backgroundAccelerated vascular aging, assessed as artificial intelligence-based vascular age (AIVA), is associated with small vessel disease that may impact brain structure and neuropsychological function.
methodsIn a cross-section of Framingham Heart Study participants, AIVA was estimated using a validated convolutional neural network trained to predict carotid-femoral pulse wave velocity from a normalized pressure waveform. Brain structure was assessed using magnetic resonance imaging with diffusion tensor imaging, and neuropsychological function was assessed using a standardized test battery. Analyses included magnetic resonance imaging (N=2313) and neuropsychological (N=3001) samples. We used multivariable linear and logistic regression to relate AIVA to brain structural and neuropsychological functional measures.
resultsThe mean±SD age across participants was 62±11 years; 56% were women. In multivariable models, higher AIVA was associated with worse markers of cerebral small vessel disease (mean white matter free water:
conclusionsPeripheral pressure waveform AIVA may be a novel, noninvasive indicator of subclinical vascular brain injury and neuropsychological function.
Indexed as
brain infarctionbrain injuriescarotid-femoral pulse wave velocitycerebral small vessel diseasesdiffusion tensor imaging
Identifiers
PMID42779540
PMCPMC13614525
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