Evidence map›Paper›PMID 42779675›Full record

ArticlebioRxiv : the preprint server for biology2026

Emerin loss of function inhibits MyoD-driven differentiation of human iPSCs into skeletal myotubes.

Tracy A Knight, Jessica Mella, Daniel Chen, Rodolfo S Ferreira, Helen C Miranda, Abigail Buchwalter

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tracy A KnightTetrad Graduate Program, University of California, San Francisco.
Jessica MellaTetrad Graduate Program, University of California, San Francisco.
Daniel ChenDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland OH, USA.
Rodolfo S FerreiraDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland OH, USA.
Helen C MirandaDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland OH, USA.ORCID 0000-0002-4064-9790
Abigail BuchwalterCardiovascular Research Institute, University of California, San Francisco.ORCID 0000-0001-7181-6961

Funding

Understanding mechanisms of heterochromatin tethering at the nuclear laminaR35GM142897 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Abigail Lynn Buchwalter · 2021 to 2026
$2.4M
Exploring modulation of Lamin A/C protein lifetime as a novel axis of regulation in heath and diseaseR01AR084208 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Abigail Lynn Buchwalter · 2024 to 2026
$1.3M
NIAMS NIH HHS R01 AR084208NIGMS NIH HHS R35 GM142897
6 · The paper itself

Abstract

Loss of function of the nuclear lamina-associated protein emerin causes Emery-Dreifuss muscular dystrophy (EDMD). Efforts to define emerin's essential functions in skeletal muscle have been limited by poor concordance between mouse models and human disease phenotypes. Here, we adapt transgene-driven differentiation of human induced pluripotent stem cells (hiPSCs) into skeletal muscle (iSMs) as a tractable human model for emerin loss of function. We find that

Identifiers

PMID42779675
PMCPMC13596264

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.