Evidence map›Paper›PMID 42779787›Full record

ArticlebioRxiv : the preprint server for biology2026

Reza Fadaei, Annie Bernstein, Elizabeth A Wayman, Azuah L Gonzalez, Keri A Tallman, Zahra Mashhadi, Abdul-Musawwir Alli-Oluwafuyi, Sergey Dikalov, MacRae F Linton, Kasey C Vickers and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Reza FadaeiDepartment of Pharmacology, Vanderbilt University.
Annie BernsteinCollege of Arts and Sciences, Vanderbilt University.ORCID 0009-0005-7511-7240
Elizabeth A WaymanCollege of Arts and Sciences, Vanderbilt University.
Azuah L GonzalezDepartment of Pathology, Microbiology, and Immunology.
Keri A TallmanDepartment of Chemistry, Vanderbilt University.
Zahra MashhadiDepartment of Pharmacology, Vanderbilt University.
Abdul-Musawwir Alli-OluwafuyiDepartment of Pharmacology, Vanderbilt University.
Sergey DikalovDepartment of Medicine, Division of Human Genetics and Clinical Pharmacology.ORCID 0000-0003-2976-6184
MacRae F LintonDivision of Cardiovascular Medicine.ORCID 0000-0002-9277-0453
Kasey C VickersDepartment of Molecular Physiology and Biophysics, Vanderbilt University.ORCID 0000-0001-5643-3102
Amanda C DoranDepartment of Molecular Physiology and Biophysics, Vanderbilt University.ORCID 0000-0002-1576-6274
Sean S DaviesDepartment of Pharmacology, Vanderbilt University.ORCID 0000-0001-9879-8062

Funding

Non-coding RNA & Bioinformatics CoreP01HL116263 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DAVIES, SEAN STEPHEN · 2014 to 2025
$24.7M
NHLBI NIH HHS P01 HL116263
6 · The paper itself

Abstract

Background: Impairments in efferocytosis, the phagocytic clearance of apoptotic cells, contribute to the development of chronic inflammation and promote the formation of large necrotic cores within atherosclerotic plaques. A better understanding of the factors that impair efferocytosis could lead to improved interventions. Many chronic inflammatory conditions feature excessive lipid peroxidation, which generates reactive lipid aldehydes that can potentially form Methods: The effects of synthetic NAMPs and lipid peroxidation on efferocytosis were measured using the Incucyte Live-Cell Analysis System to monitor rate of ingestion of CypHer-labeled apoptotic cells by cultured bone marrow-derived macrophages in real time. The extent of NAMP formation under various conditions was examined using liquid chromatography coupled with mass spectrometry. Results: Several representative species of NAMPs ( Conclusions: NAMPs accumulate under conditions associated with lipid peroxidation and inhibit the ability of macrophages to carry out efferocytosis.

Indexed as

efferocytosisferroptosisLipid peroxidationmacrophagesreactive lipid aldehydes

Identifiers

PMID42779787
PMCPMC13596448

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.