Evidence map›Paper›PMID 42779895›Full record

ArticlebioRxiv : the preprint server for biology2026

Calmodulin mutation N54I causes autosomal dominant CPVT in mice.

Daniel J Blackwell, Nieves Gomez-Hurtado, Kyungsoo Kim, Paxton A Ritschel, Carlos Tellet-Cabiya, Huan He, Jose R Pinto, Eric Delpire, Bjorn C Knollmann

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniel J BlackwellDepartment of Medicine, Vanderbilt University Medical Center, Nashville 37235, Tennessee, United States.
Nieves Gomez-HurtadoDepartment of Medicine, Vanderbilt University Medical Center, Nashville 37235, Tennessee, United States.
Kyungsoo KimDepartment of Medicine, Vanderbilt University Medical Center, Nashville 37235, Tennessee, United States.
Paxton A RitschelDepartment of Medicine, Vanderbilt University Medical Center, Nashville 37235, Tennessee, United States.
Carlos Tellet-CabiyaDepartment of Medicine, Vanderbilt University Medical Center, Nashville 37235, Tennessee, United States.
Huan HeTranslational Science Laboratory, College of Medicine, Florida State University, Tallahassee, FL.
Jose R PintoDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA.
Eric DelpireDepartment of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Bjorn C KnollmannDepartment of Medicine, Vanderbilt University Medical Center, Nashville 37235, Tennessee, United States.ORCID 0000-0003-4956-9735

Funding

Toward a Mechanism-Based Approach to Treating Cardiac ArrhythmiaR35HL144980 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KNOLLMANN, BJORN C · 2019 to 2025
$7.1M
The mechanisms of cardiac thin filament regulation in health and disease.R01HL160966 · NHLBI · OLD DOMINION UNIVERSITY · PI CHASE, P. BRYANT, GALKIN, VITOLD · 2022 to 2025
$2.3M
Therapeutic Development of the RyR2-Inhibitor ent-Verticilide for Atrial FibrillationR01HL183508 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Bjorn C Knollmann · 2026 to 2026
$1.7M
Therapeutic Development of RyR2-Inhibiting Flecainide Analogs for Arrhythmia PreventionR01HL177564 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Bjorn C Knollmann · 2026 to 2026
$857k
Establishing the role of structural elements in cardiac muscle contractionR01HL179825 · NHLBI · FLORIDA STATE UNIVERSITY · PI Vitold Galkin, Michelle Parvatiyar · 2026 to 2026
$703k
NHLBI NIH HHS R01 HL160966NHLBI NIH HHS R01 HL177564NHLBI NIH HHS R01 HL179825NHLBI NIH HHS R01 HL183508NHLBI NIH HHS R35 HL144980
6 · The paper itself

Abstract

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia syndrome characterized by stress- or catecholamine-induced ventricular arrhythmias in the absence of overt structural heart disease. Mutations in

Indexed as

CalciumCalmodulinCatecholaminergic Polymorphic Ventricular TachycardiaLong QT SyndromeRyR2 Calcium Release ChannelSarcoplasmic Reticulum

Identifiers

PMID42779895
PMCPMC13596268

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.