Evidence map›Paper›PMID 42779938›Full record

ArticlebioRxiv : the preprint server for biology2026

Stepwise reorganization of chromosome conformation and nuclear organization during stem cell differentiation.

Xiangru Huo, Denis L Lafontaine, Thomas M Reimonn, Liyan Yang, Richard Siller, Jack Huey, Jiang Min, Aleksandra A Galitsyna, Vedat Yilmaz, Krishna Mohan Parsi and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xiangru HuoDepartment of Systems Biology, UMass Chan Medical School, Worcester, MA, USA.
Denis L LafontaineDepartment of Systems Biology, UMass Chan Medical School, Worcester, MA, USA.
Thomas M ReimonnDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.
Liyan YangDepartment of Systems Biology, UMass Chan Medical School, Worcester, MA, USA.
Richard SillerProgram in Molecular Medicine, UMass Chan Medical School, Worcester, MA, USA.
Jack HueyProgram in Molecular Medicine, UMass Chan Medical School, Worcester, MA, USA.
Jiang MinProgram in Molecular Medicine, UMass Chan Medical School, Worcester, MA, USA.
Aleksandra A GalitsynaInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Vedat YilmazDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.
Krishna Mohan ParsiProgram in Molecular Medicine, UMass Chan Medical School, Worcester, MA, USA.
Emily NavarreteInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Hoang TranDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.
Leonid MirnyInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-0785-5410
Rene MaehrProgram in Molecular Medicine, UMass Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-9520-3382
Johan H GibcusDepartment of Systems Biology, UMass Chan Medical School, Worcester, MA, USA.
Job DekkerDepartment of Systems Biology, UMass Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-5631-0698
Nezar AbdennurDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-5814-0864

Funding

Center for 3D Structure and Physics of the GenomeUM1HG011536 · NHGRI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DEKKER, JOB, MIRNY, LEONID A · 2020 to 2024
$11.8M
CTSA Predoctoral T32 at University of MassachusettsT32TR005445 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Kate L Lapane · 2026 to 2026
$328k
Stability of the folded genomeF31HG011583 · NHGRI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LAFONTAINE, DENIS · 2020 to 2022
$101k
NCATS NIH HHS T32 TR005445NHGRI NIH HHS F31 HG011583NHGRI NIH HHS UM1 HG011536
6 · The paper itself

Abstract

Nuclear organization is a fundamental feature of cell identity and cell fate determination. Compared with differentiated cells, pluripotent stem cells exhibit markedly distinct nuclear architecture at multiple levels, including chromosome folding, lamina association, histone modification landscapes and nuclear body organization. Although individual aspects of this reorganization have been characterized, how and in what order these features are remodeled as cells commit to a lineage remains poorly understood. Here, we temporally map nuclear reorganization across five stages of an

Identifiers

PMID42779938
PMCPMC13596353

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.