Evidence map›Paper›PMID 42779977›Full record

ArticlebioRxiv : the preprint server for biology2026

Clustered structural variant hotspots enable oncogenic addiction and plasticity in osteosarcoma.

Shreya Raman, Thorsten Kaltenbacher, David Merrell, Kavya Prasad, Yutaro Tanaka, Jakob Weiss, Emily Iannetta, Byron Butaney, Emily Jorswieck, Amr Salem and 20 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Shreya RamanDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Thorsten KaltenbacherDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
David MerrellBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Kavya PrasadBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Yutaro TanakaDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.ORCID 0009-0004-1060-7065
Jakob WeissBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Emily IannettaDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Byron ButaneyDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Emily JorswieckDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Amr SalemDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Lorena Lazo De La VegaDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Evelina CecaDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Julia M W WongDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Suzanne J ForrestDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Kelly KlegaDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Mohammad TanhaemamiDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Cora A RickerDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Jinyu WangSchool of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Diane M DiehlBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Jeremy JohnsonBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Carrie CibulskisBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Kristy Schlueter-KuckBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Liam Q AlleyDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Natalie B CollinsDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.ORCID 0000-0003-2980-9244
Cheng-Zhong ZhangDepartment of Pathology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8825-7158
David S ShulmanDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Brian D CromptonDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Katherine A JanewayDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Gad GetzBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Riaz GillaniDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.

Funding

Participant Engagement UnitU2CCA252974 · NCI · BROAD INSTITUTE, INC. · PI MACK, JENNIFER W · 2020 to 2025
$16.6M
Detecting DICER1: A global partnership to cure pediatric lung cancerR37CA244940 · NCI · CHILDREN'S HOSPITALS AND CLINICS · PI Kris Ann Pinekenstein Schultz · 2020 to 2026
$2.4M
Dissecting the role of DNA damage repair deficiency in Ewing sarcoma pathogenesis for improved risk stratification and treatmentK08CA276701 · NCI · DANA-FARBER CANCER INST · PI Riaz Gillani · 2023 to 2026
$788k
NCI NIH HHS K08 CA276701NCI NIH HHS R37 CA244940NCI NIH HHS U2C CA252974
6 · The paper itself

Abstract

The genomic landscape of osteosarcoma, the most common bone cancer worldwide, is among the most structurally complex of all human malignancies. The identification of recurrent and functionally consequential patterns has thus remained a challenge. Across 236 whole-genome sequencing osteosarcoma samples, we uncovered five genomic hotspots of clustered structural variation collectively altered in 58% of tumors. Four were associated with amplification of oncogenes (

Identifiers

PMID42779977
PMCPMC13596379

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.