ArticleFrontiers in pharmacology2026
Phellinus igniarius-derived carbon dots suppress liver cancer through the ROS/MAPK signaling axis.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Liver cancer is one of the most common and highly lethal malignancies worldwide, and current therapeutic strategies remain limited, posing significant clinical challenges. Thermal processing of natural products is not only used for the extraction of active constituents, but may also induce structural reconstruction and bioactivity transformation of endogenous components. Recent studies have demonstrated that certain natural products can generate carbon dots (CDs) with specific biological activities under high-temperature conditions, suggesting that these nanoparticles may serve as novel active components formed during thermal processing. Phellinus igniarius, a traditional medicinal fungus, possesses anti-inflammatory and immunomodulatory activities. However, the formation of carbon dots during its thermal processing and their biological functions have not been systematically investigated. In this study, Phellinus igniarius-derived carbon dots (PI-CDs) were synthesized using a hydrothermal method, and their antitumor activities and underlying mechanisms were systematically evaluated both
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