SynthesisFrontiers in aging neuroscience2026
Sleep-neuroinflammation interactions in Alzheimer's disease: a systematic review of biomarker pathways.
Synthesis in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Although sleep disturbances are increasingly associated with Alzheimer's disease (AD), the mechanistic interplay between sleep physiology, neuroinflammation and AD-related pathology is not fully understood. The question of whether disrupted sleep contributes to neurodegeneration or merely reflects early pathological processes is still being debated. In accordance with PRISMA-2020 guidelines, we conducted a systematic review to synthesize the current evidence linking objectively measured sleep alterations, glial activation and AD-related outcomes. A comprehensive search of PubMed, Scopus, EMBASE and Web of Science (January 2000 - June 2026) identified 40 original studies that met the predefined inclusion criteria. These studies included objective sleep assessments (polysomnography, electroencephalography, actigraphy, or experimental sleep manipulation), direct evaluations of neuroinflammatory or glial markers, and assessments of amyloid-
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.