Evidence map›Paper›PMID 42780631›Full record

ArticleBioactive materials2027

Ultrasound-activated piezoelectric patch enhances mitophagy and synergistic anti-inflammation to promote neurological repair after TBI.

Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu

Abstract read
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In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wei LiThe First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, 730000, PR China.
Runzhe HuangBeijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites Bionanomaterials & Translational Engineering Laboratory, Beijing Key Laboratory of Green Chemicals Biomanufacturing, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, PR China.
Qingyuan WuDepartment of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, 100084, PR China.
Pengbo ZhouThe First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, 730000, PR China.
Dangli RenCenter Laboratory for Neurological Diseases, Characteristic Medical Center of People's Armed Police Forces, Tianjin, 300162, PR China.
Jingjing WangCenter Laboratory for Neurological Diseases, Characteristic Medical Center of People's Armed Police Forces, Tianjin, 300162, PR China.
Hanjie NiuCenter Laboratory for Neurological Diseases, Characteristic Medical Center of People's Armed Police Forces, Tianjin, 300162, PR China.
Zemeng LiCenter Laboratory for Neurological Diseases, Characteristic Medical Center of People's Armed Police Forces, Tianjin, 300162, PR China.
Hongtao SunThe First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, 730000, PR China.
Huiyu LiuBeijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites Bionanomaterials & Translational Engineering Laboratory, Beijing Key Laboratory of Green Chemicals Biomanufacturing, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial dysfunction following traumatic brain injury (TBI) is a central pathological driver of secondary neuronal damage and neuroinflammation. Mitophagy, a key mitochondrial quality control mechanism, is essential for maintaining neuronal homeostasis and promoting injury repair. However, achieving spatiotemporally precise regulation of mitophagy while simultaneously modulating the neuroimmune microenvironment remains a major challenge. Here, we design an implantable piezoelectric patch that, upon activation by low-intensity pulsed ultrasound (LIPUS), generates controllable local electrical signals at the injury site and directly acts on damaged neurons. The patch predominantly upregulates Piezo1-sensitive mechanotransduction and induces a transient elevation of mitochondrial Ca

Indexed as

MitophagyNeural repairPiezoelectric patchSynergistic anti-inflammatory effectTBI

Identifiers

PMID42780631
PMCPMC13598528

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.