Evidence map›Paper›PMID 42780699›Full record

ArticlePrecision radiation oncology2026

Expert consensus on clinical trial design guidelines for FLASH radiotherapy.

Hui Luo, Chen Cheng, Chengliang Yang, Bing Li, Jiandong Zhang, Jinbo Yue, Zhaoyang Lou, Hui Liu, Jing Cai, Hong Ge

Abstract read
In one paragraph

Article in Precision radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hui LuoDepartment of Radiation Oncology The Affiliated Cancer Hospital of Zhengzhou University Zhengzhou China.ORCID https://orcid.org/0000-0003-2149-6546
Chen ChengDepartment of Strategy and Business The Affiliated Cancer Hospital of Zhengzhou University Zhengzhou China.
Chengliang YangDepartment of Radiation Oncology The Affiliated Cancer Hospital of Zhengzhou University Zhengzhou China.
Bing LiDepartment of Radiation Oncology The Affiliated Cancer Hospital of Zhengzhou University Zhengzhou China.ORCID https://orcid.org/0000-0001-6983-7253
Jiandong ZhangDepartment of Radiation Oncology Shandong Provincial Qianfoshan Hospital Jinan China.
Jinbo YueDepartment of Radiation Oncology Shandong Cancer Hospital Jinan China.
Zhaoyang LouDepartment of Radiation Oncology The Affiliated Cancer Hospital of Zhengzhou University Zhengzhou China.
Hui LiuDepartment of pathology and Pathophysiology School of Basic Medical Sciences College of Medicine Zhengzhou University Zhengzhou China.ORCID https://orcid.org/0009-0003-8474-0494
Jing CaiDepartment of Health Technology and Informatics The Hong Kong Polytechnic University Hong Kong SAR China.ORCID https://orcid.org/0000-0001-6934-0108
Hong GeDepartment of Radiation Oncology The Affiliated Cancer Hospital of Zhengzhou University Zhengzhou China.ORCID https://orcid.org/0000-0003-4270-2556

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, ultra-high dose-rate FLASH radiotherapy (FLASH-RT) has emerged as a prominent research focus in radiation oncology. A series of preclinical data indicate that FLASH-RT can achieve tumor-killing efficacy that is not inferior to that of conventional radiotherapy (CONV-RT) while significantly reducing radiation damage to normal tissues. This distinctive tissue-sparing effect is known as the "FLASH effect." Rapid progress has been made in the clinical translation and application of FLASH-RT. Against this backdrop, the China Anti-Cancer Association Radiation Oncology Committee and the Chinese Medical Doctor Association Radiation Oncology Physician Committee gathered a group of experts and compiled the "Expert Consensus on Clinical Trial Design Guidelines for FLASH Radiotherapy" based on the latest domestic and international research advancements. This document summarizes the latest advances in FLASH-RT and offers practical guidance for its design and translational application in future clinical trials.

Indexed as

clinical trial designexpert consensusFLASH radiotherapyradiation‐induced normal tissue toxicitytranslational application

Identifiers

PMID42780699
PMCPMC13598684

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.