ArticleKidney international reports2026
Systematic Review of Exercise Interventions and HRQOL in Predialysis CKD.
Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Introduction: Health-related quality of life (HRQOL) is frequently impaired among individuals with chronic kidney disease (CKD), even before dialysis initiation. Exercise has been proposed as a strategy to improve HRQOL, but the extent of this association remains unclear in patients with predialysis CKD. This systematic review aimed to characterize the literature examining the relationship between exercise and HRQOL in patients with predialysis CKD. Methods: A systematic review was conducted, guided by Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines and its extension for reviews without meta-analysis. PubMed and Embase were searched in August 2025. Eligible studies included observational or interventional studies assessing physical activity or exercise among patients with CKD stages 1-5 (not on dialysis) and reporting HRQOL outcomes. Results: A total of 18 publications representing 16 randomized controlled trials met the inclusion criteria. Most studies evaluated aerobic exercise interventions, typically walking-based programs performed for 30-60 minutes, 2-4 times per week for 12 weeks to 6 months. HRQOL was assessed using standardized patient-reported outcome measures. Eleven studies reported improvements in HRQOL after exercise interventions, primarily in physical and social domains, including improvements in fatigue, sleep quality, pain, uremic symptoms, social functioning, and social interaction, whereas 5 studies reported no significant change. Conclusion: Exercise interventions appear to improve HRQOL among patients with predialysis CKD, particularly in physical and social domains, although heterogeneity in interventions and outcome measures limits comparability. Future interventions should aim for clinically meaningful improvements besides statistical significance.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.