ArticleJournal of medical biochemistry2026
Circulating tumor-associated biomarkers and pulmonary function in lung cancer patients with comorbid COPD: A retrospective prognostic analysis.
Article in Journal of medical biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Chronic obstructive pulmonary disease (COPD) is closely associated with lung cancer development and progression through persistent systemic inflammation and immune-biochemical alterations. Circulating tumor-associated biochemical biomarkers may reflect disease severity and provide valuable prognostic information. This study aimed to explore the potential association between circulating tumor markers and prognosis in lung cancer patients with comorbid COPD, acknowledging the exploratory nature of this retrospective analysis. Methods: Clinicopathological characteristics and circulating biochemical biomarkers, including carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), carbohydrate antigen 153 (CA153), carbohydrate antigen 199 (CA199), cytokeratin-19 fragment (CYFRA21-1), and vascular endothelial growth factor (VEGF), were analyzed. Multivariate logistic regression was performed to identify independent prognostic biochemical predictors. Receiver operating characteristic (ROC) curve analysis was used to evaluate prognostic performance.
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