ReviewJournal of conservative dentistry and endodontics2026
Noncoding RNA networks in endodontic regeneration: Current evidence and future directions.
Review in Journal of conservative dentistry and endodontics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: This narrative review provides a consolidated existing literature on regulatory functions of noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long ncRNAs, and circular RNAs (circRNAs) in pulp-dentin complex regeneration. Methods: A background search was implemented utilizing data from PubMed, Scopus, and Web of Science to determine research conducted between January 2010 and April 2026. In particular, studies focused on experimental Results: Research indicates that ncRNAs act as master regulators influencing stem cell differentiation, new blood vessels formation and generating a layer of hard tissue such as dentin, primarily through the competing endogenous RNA networks of epigenetic changes and posttranscriptional regulation of genes. The development of transcriptomics of individual cells has revealed cellular diversity and complex regulatory interactions during pulp injury and recovery. Recent animal studies and clinical molecular investigations have revealed that miRNAs bound to exosomes and circRNA-mediated regulatory circuits can improve pulp-dentin regeneration and also function as diagnostic biomarkers and therapeutic objective. Conclusion: ncRNAs serve as an essential regulatory tier in regenerative endodontics that connects molecular biology into clinical translational. The combination of multiomics analyses along with biomaterial-based delivery systems can lead to precision, mechanism-driven regenerative therapies and may also transform future endodontic treatment modalities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.