Evidence map›Paper›PMID 42782214›Full record

ArticleMedical physics2026

Fast and robust T1 mapping based on a 3D dual-echo UTE sequence (PETALUTE) for superparamagnetic iron oxide nanoparticle (SPION) biodistribution assessment.

Zhen Jiang, Stephen Sawiak, Alexandra Lipka, Xin Shen, Uzay Emir, Ali Özen, Mark Chiew, Justin Geise, Joseph Speth, Deng-Yuan Chang and 5 more

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Article in Medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zhen JiangSchool of Health Sciences, College of Health and Human Sciences, Purdue University, West Lafayette, Indiana, USA.
Stephen SawiakDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Alexandra LipkaSchool of Health Sciences, College of Health and Human Sciences, Purdue University, West Lafayette, Indiana, USA.
Xin ShenDepartment of Radiology, University of California San Diego, San Diego, California, USA.
Uzay EmirDepartment of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Ali ÖzenDepartment of Radiology, Medical Physics, Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany.
Mark ChiewNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Justin GeiseSchool of Health Sciences, College of Health and Human Sciences, Purdue University, West Lafayette, Indiana, USA.
Joseph SpethSchool of Health Sciences, College of Health and Human Sciences, Purdue University, West Lafayette, Indiana, USA.
Deng-Yuan ChangSchool of Health Sciences, College of Health and Human Sciences, Purdue University, West Lafayette, Indiana, USA.
Jessica VeenstraSchool of Health Sciences, College of Health and Human Sciences, Purdue University, West Lafayette, Indiana, USA.
Mitchell GabalskiWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.
Luis SolorioWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.
Gregory TamerWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.
Matthew ScarpelliSchool of Health Sciences, College of Health and Human Sciences, Purdue University, West Lafayette, Indiana, USA.

Funding

Eli Lilly and CompanyNIHWellcome Trust
6 · The paper itself

Abstract

backgroundSuperparamagnetic iron oxide nanoparticles (SPIONs), such as ferumoxytol, are promising theranostic agents that can be assessed with MRI. Relaxation time mapping can provide reproducible and quantitative biomarkers of SPION distribution, suitable for longitudinal and cross-individual studies. However, conventional approaches suffer from strong susceptibility artifacts, long echo times (TE), and prolonged scan times, which limit the accurate quantification of SPION biodistribution. PURPOSE: To address the limitations of conventional approaches, this study aimed to develop a fast, B

methodsAgarose phantoms containing 0-5000 µg/mL ferumoxytol were scanned on a preclinical 7T MRI system using PETALUTE and RARE-VTR (rapid acquisition with relaxation enhancement and variable repetition time). PETALUTE T

resultsIn the phantom study, PETALUTE preserved positive contrast for ferumoxytol at all concentrations, whereas the conventional RARE-VTR sequence exhibited signal loss and hypointensity. For PETALUTE, there was a significant linear correlation between R

conclusionsThe proposed PETALUTE-based T

Indexed as

Imaging, Three-DimensionalMagnetic Iron Oxide NanoparticlesMagnetic Resonance ImagingAnimalsFemaleFerrosoferric OxideMicePhantoms, ImagingTime FactorsTissue DistributionFerrosoferric OxideferumoxytolT1 mappingUTE

Identifiers

PMID42782214
PMCPMC13603949

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.