Evidence map›Paper›PMID 42782801›Full record

ArticleCells2026

AUG-Dependent Translation of Antisense Repeat Transcripts Contributes to Dipeptide Repeat Protein Production in

Sandra Almeida, Yuanzheng Gu, Mark W Kankel

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sandra AlmeidaDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID 0000-0002-5648-7239
Yuanzheng GuNeuromuscular & Movement Disorders, Biogen, Cambridge, MA 02142, USA.
Mark W KankelNeuromuscular & Movement Disorders, Biogen, Cambridge, MA 02142, USA.

Funding

Upregulation of progranulin in a human iPSC-derived neurovascular model of GRN-associated Frontotemporal DementiaR21AG085076 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ALMEIDA, SANDRA · 2023 to 2023
$461k
Investigating Translational De-repression as a Mechanism to Increase Progranulin Levels in iPSC-derived Patient NeuronsR21NS112766 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ALMEIDA, SANDRA · 2019 to 2019
$461k
Characterization of TASK-1 Modulation of Dipeptide Repeat Protein-Mediated Toxicity in iPSC-derived C9ORF72 Patient Neurons.R21NS119952 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ALMEIDA, SANDRA · 2020 to 2020
$461k
NIA NIH HHS R21 AG085076NIH HHS 1R21AG085076-25NIH HHS 1R21NS112766-24NIH HHS R21NS119952NINDS NIH HHS R21 NS112766NINDS NIH HHS R21 NS119952
6 · The paper itself

Abstract

A hexanucleotide repeat expansion in

Indexed as

C9orf72 ProteinDipeptidesDNA Repeat ExpansionProtein BiosynthesisRNA, AntisenseAmyotrophic Lateral SclerosisFrontotemporal DementiaHumansMotor NeuronsOligonucleotides, AntisenseC9orf72 ProteinC9orf72 protein, humanDipeptidesOligonucleotides, AntisenseRNA, AntisenseALSASOdipeptide repeat proteinFTDiPSC-derived neuronsrepeat RNA translation

Identifiers

PMID42782801
PMCPMC13605190

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.