ArticleBiosensors2026
Continuous Measurement of Spatially Resolved Red Blood Cell Aggregation Using Multiple Side-Branch Channels.
Article in Biosensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Red blood cell (RBC) aggregation is an important hemorheological property that influences blood viscosity, microcirculation, and stored-blood quality. However, conventional measurements commonly require repeated flow cessation or flow-rate modulation, limiting continuous monitoring and providing little information on spatial heterogeneity. This study presents a microfluidic platform for the spatiotemporal mapping of RBC aggregation during continuous blood flow. Multiple high-resistance side chambers connected to a main channel create low-shear-rate regions for aggregation while maintaining high shear in the main channel for RBC disaggregation. Flow rates and shear rates are evaluated using a hydraulic circuit model, numerical simulation, and micro-PIV measurements. An aggregation index (AI) map is introduced to quantify spatial and temporal changes in the side chambers. AI remains high and stable at flow rates of 0.5~1 mL/h. RBC aggregation increases significantly at concentrations of 15 mg/mL or with more dextran solution (
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