ArticleMetabolites2026
Integrated Transcriptomics and Metabolomics to Reveal the Regulatory Mechanisms of Flavonoid Biosynthesis in
Article in Metabolites, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
background
methodsIn this study, a pot experiment was performed to investigate the effects of different nitrogen treatments on the growth performance and yield of
resultsNitrogen fertilization significantly promoted stem elongation, branch number, and yield formation. The maximum stem length, branch number, and single-plant yield were recorded in the 0.3 g N/kg treatment group as reaching 80.74 cm, 37.30, and 123.64 g/plant, respectively. Transcriptomic screening yielded 10,880 differentially expressed genes (DEGs), and the number of downregulated DEGs was consistently higher than upregulated DEGs across all comparison groups. Metabolomic analysis identified a total of 3356 differentially accumulated metabolites, including 168 differential flavonoid metabolites. With the increase in nitrogen application rate, most flavonoid compounds, such as chlorogenic acid, 5-hydroxyferulic acid, and 4-hydroxycinnamic acid, exhibited a significantly downregulated accumulation pattern. An integrated transcriptomic and metabolomic analysis revealed that the differential flavonoid metabolites and functional genes were predominantly enriched in the phenylpropanoid biosynthesis, flavonoid biosynthesis, and flavone and flavonol metabolism pathways. The decreased expression of key structural genes, including
conclusionsNitrogen supplementation increases the yield of
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