Evidence map›Paper›PMID 42784302›Full record

GuidelineToxins2026

Dystonia 3×3: A Training Guideline for Beginners in Botulinum Neurotoxin Treatment of Cervical Dystonia.

Sebastian Paus, Andreas Funke, Jürgen Hamacher, Bernhard Haslinger, Jan Heckelmann, Chi Wang Ip, Wolfgang H Jost, Anatol Kivi, Stephan Klebe, John-Ih Lee and 7 more

Abstract readPractice Guideline
In one paragraph

Guideline in Toxins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sebastian PausDepartment of Neurology, GFO Kliniken Troisdorf, 53844 Troisdorf, Germany.
Andreas FunkeNeurologie am Funkerberg, 15711 Königs Wusterhausen, Germany.ORCID 0000-0002-2606-2563
Jürgen HamacherPraxis NeuroMotion, 45219 Essen, Germany.
Bernhard HaslingerDepartment of Neurology, Technical University Munich, 81675 Munich, Germany.
Jan HeckelmannDepartment of Neurology, RWTH University Hospital Aachen, 52074 Aachen, Germany.ORCID 0000-0003-0597-3269
Chi Wang IpDepartment of Neurology, University Hospital Würzburg, 97080 Würzburg, Germany.
Wolfgang H JostParkinson-Klinik Ortenau, 77709 Wolfach, Germany.ORCID 0000-0002-8574-3297
Anatol KiviDepartment of Neurological Rehabilitation and Physical Therapy, Vivantes Klinikum Spandau, 13585 Berlin, Germany.ORCID 0009-0000-2959-2378
Stephan KlebeDepartment of Neurology, Knappschaft Kliniken Recklinghausen, 45657 Recklinghausen, Germany.
John-Ih LeeDepartment of Neurology and Clinical Neurophysiology, GFO Kliniken Rhein-Berg, 51465 Bergisch Gladbach, Germany.
Ebba LohmannDepartment of Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany.
Frederic MackDepartment of Neurology, GFO Kliniken Troisdorf, 53844 Troisdorf, Germany.
Axel SchrammNeuroPraxis Fuerth, 90762 Fuerth, Germany.
Andrea StennerMovement Disorders Competence Center, Medizinisches Versorgungszentrum Zwickau, 08060 Zwickau, Germany.
Pawel TacikCenter for Neurology, Department of Parkinson's Disease, Sleep and Movement Disorders, University Hospital Bonn, 53127 Bonn, Germany.
Uwe WalterDepartment of Neurology, Rostock University Medical Center, 18147 Rostock, Germany.ORCID 0000-0002-6280-785X
David T WeiseDepartment of Neurology, Asklepios Fachklinikum Stadtroda, 07646 Stadtroda, Germany.ORCID 0000-0002-5772-6609

Funding

Ipsen (Germany)
6 · The paper itself

Abstract

Cervical dystonia (CD) is a hyperkinetic movement disorder characterized by involuntary muscle contractions leading to abnormal postures of the head and neck. The injection of botulinum neurotoxin type A (BoNT-A) into the muscles involved is the treatment of choice for CD. BoNT-A therapy of CD requires appropriate training, which has not been standardized in Germany. To address the key challenges in BoNT-A education, an expert panel developed a simplified step-by-step treatment guideline for beginners, adapted from the established Col-Cap-Concept ("Dystonia 3×3"). Based on expert consensus, recommendations were developed for the core clinical elements of BoNT-A treatment in CD-recognition of the movement pattern, identification of target muscles, development of an injection plan, ultrasound-guided injection, and dosing, taking into account the target audience of the guideline. As such, Dystonia 3×3 provides a user-friendly beginner's guidebook, enhancing accessibility and standardization of CD treatment training. Further research is required to evaluate its clinical efficacy and suitability for training.

Indexed as

Botulinum Toxins, Type ANeuromuscular AgentsTorticollisHumansBotulinum Toxins, Type ANeuromuscular Agentsbotulinum neurotoxin type Acervical dystoniaCol-Cap-Conceptexpert consensustraining conceptultrasound

Identifiers

PMID42784302
PMCPMC13611707

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.