ArticleFrontiers in neurology2026
Biomechanical optimization of rolling manipulation for lumbar muscle strain: a study protocol of cerebral hemodynamic responses and clinical efficacy using fNIRS.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Lumbar muscle strain (LMS) is a common chronic soft tissue injury disorder, and Tuina, especially Tuina rolling manipulation, is widely used for its management. However, standardized force parameters based on biomechanical effects have not yet been established, and the analgesic mechanisms of rolling manipulation remain insufficiently understood, particularly regarding its influence on cortical hemodynamic responses during manual intervention. Existing studies are fragmented, lacking systematic investigation of the entire chain from pain stimulation-induced cortical hemodynamic responses, to biomechanically optimized manipulation parameters, and to clinical efficacy. Therefore, this study aims to combine functional near-infrared spectroscopy (fNIRS) with biomechanical detection to explore cortical hemodynamic changes induced by pain stimulation, determine the optimal pressure parameters of rolling manipulation and explore the cortical hemodynamic responses associated with rolling manipulation treatment for lumbar muscle strain. Methods and design: This is a three-part, hierarchical mixed-methods study. Part 1 (Observational): We will compare cerebral hemodynamic responses (via fNIRS) between LMS patients ( Discussion: This protocol combines neuroimaging and biomechanical assessments to explore the potential association between peripheral biomechanical responses and cortical hemodynamic changes during Tuina rolling manipulation, optimize key operational parameters, and provide preliminary evidence for future clinical research and application.
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