ArticleFrontiers in bioengineering and biotechnology2026
The PEDIAVALVE project - tissue-engineered pulmonary valves for paediatric valvular replacement.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Current paediatric options for pulmonary heart valve (PHV) substitutes are imperfect, requiring numerous reinterventions until maturity. Substitutes with a diameter under 15 mm have a limited service life, underscoring the critical need for small-diameter valves. To address this need, we obtained and tested decellularized, DNA-depleted, small-diameter valvular substitutes using tissue-engineered lamb PHVs. Lamb PHVs were subjected to a decellularization perfusion protocol, yielding a 3D extracellular matrix (ECM)- derived acellular scaffold. Sterility, residual nuclei (histology) and DNA content were assessed. Hemodynamic performance was assessed in a dedicated heart valve bioreactor, compared with freshly harvested PHV. Cytocompatibility was assessed using fibroblasts and endothelial cells, and the
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