ArticleFrontiers in neurology2026
Safety and efficacy of endovascular treatment for progressive large vessel occlusion stroke presenting 24-72 h after onset: a propensity score-matched analysis.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and purpose: To evaluate the efficacy and safety of endovascular treatment (EVT) versus standard medical therapy (SMT) in patients with progressive large vessel occlusion (LVO) presenting 24-72 h after onset. Methods: We retrospectively analyzed patients with progressive LVO and perfusion mismatch (tissue window) between 24 and 72 h after onset. Propensity score matching (PSM) was performed to balance baseline characteristics. The primary outcome was functional independence (modified Rankin Scale [mRS] 0-2) at 90 days. Secondary outcomes included 90-day mortality and symptomatic intracranial hemorrhage (sICH). Results: A total of 164 patients were included (EVT, Conclusion: For progressive LVO patients presenting 24-72 h after onset with favorable perfusion imaging, EVT was associated with improved functional outcomes and lower mortality, without a significant increase in hemorrhage risk. Furthermore, good collateral circulation is a statistically significant factor associated with EVT benefit.
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