Evidence map›Paper›PMID 42787666›Full record

ArticleIranian journal of basic medical sciences2026

Melatonin alleviates ferroptosis in lens epithelial cells via regulating METTL14 expression.

Huirui Liu, Fengchun Kang, Junyao Lu, Jialin Luo, Yi Gao, Zijian Yu, Qi An, Chen Yang, Liyao Sun, Hongyan Ge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of basic medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Huirui LiuEye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Fengchun KangEye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Junyao LuThe Key Laboratory of Cardiovascular Disease Acousto-Optic Electromagnetic Diagnosis and Treatment in Heilongjiang Province, The First Affiliated Hospital, Harbin Medical University, Harbin, China.
Jialin LuoEye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Yi GaoEye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Zijian YuEye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Qi AnEye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Chen YangEye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Liyao SunEye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Hongyan GeEye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Ferroptosis in lens epithelial cells (LECs) is increasingly recognized as a key pathological process in cataract formation, driven by oxidative stress, lipid peroxidation, and aberrant RNA modification. This study investigated the role of METTL14 in UVB-induced ferroptosis in LECs and explored the protective mechanism of melatonin (MT). Materials and Methods: mRNA and protein levels of METTL14 and ferroptosis-related markers (GPX4, SLC7A11) were quantified. Lipid reactive oxygen species (ROS), malondialdehyde (MDA), and glutathione levels were measured to assess ferroptotic activity. Mitochondrial structure and function were evaluated using transmission electron microscopy, mitochondrial membrane potential analysis, and ATP quantification. Results: UVB irradiation significantly up-regulated METTL14 expression and promoted ferroptosis in LECs. MT treatment reduced METTL14 expression, suppressed ferroptosis Conclusion: MT inhibits METTL14-mediated ferroptosis in LECs, reduces lipid peroxidation, and restores mitochondrial function, thereby slowing cataract progression. These findings highlight METTL14 as a critical regulator of ferroptosis and support MT as a promising therapeutic strategy for cataract prevention and treatment.

Indexed as

CataractEpithelial cellsFerroptosisLens crystallineMelatoninN6-methyladenosineOxidative stressUltraviolet rays

Identifiers

PMID42787666
PMCPMC13602880

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.