Evidence map›Paper›PMID 42787891›Full record

ArticleiScience2026

Population scale analysis reveals gut microbiome diversity and functional shifts linked to obesity.

Li-Fang Yeo, Joonatan Palmu, Aki S Havulinna, Dattatray Mongad, Katariina Pärnänen, Veikko Salomaa, Leo Lahti, Rob Knight, Teemu Niiranen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Li-Fang YeoDivision of Medicine, Turku University Hospital, Turku, Finland.
Joonatan PalmuDivision of Medicine, Turku University Hospital, Turku, Finland.
Aki S HavulinnaDepartment of Computing, University of Turku, Turku, Finland.
Dattatray MongadDepartment of Computing, University of Turku, Turku, Finland.
Katariina PärnänenDepartment of Computing, University of Turku, Turku, Finland.
Veikko SalomaaDepartment of Internal Medicine, University of Turku, Turku, Finland.
Leo LahtiDepartment of Computing, University of Turku, Turku, Finland.
Rob KnightDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Teemu NiiranenDivision of Medicine, Turku University Hospital, Turku, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the relationship between the gut microbiota and two obesity indicators, body mass index (BMI) and waist-hip ratio (WHR) in a well-phenotyped random population sample of 5846 participants. Associations were tested using multivariable-adjusted linear models and validated for BMI in an external cohort of 275 individuals. First, alpha diversity measured by Shannon was inversely associated with obesity but not observed species richness. Second, BMI was significantly associated with beta diversity (Bray Curtis) although there was no obvious clustering. Third, Bacteroidota:Firmicutes ratio was not associated with BMI or WHR. Finally, our study revealed that the gut microbiome of individuals with obesity was enriched with inflammation-associated species involved in lipid metabolism and pathways related to folate precursor, membrane lipid proteins and tRNA charging. Lean individuals were enriched in bacteria linked to cellulose breakdown.

Indexed as

cohortcross-sectionalgut microbiomeobesity

Identifiers

PMID42787891
PMCPMC13602261

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.