ArticleCureus2026
Symptom Burden in Postural Orthostatic Tachycardia Syndrome (POTS) and Endometriosis: A Retrospective Cohort Study.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
objectiveThe objective of this study is to evaluate differences in patient-reported symptom outcomes among individuals with postural orthostatic tachycardia syndrome (POTS) stratified by the presence or absence of co-occurring endometriosis.
methodsWe conducted a retrospective cohort analysis of 458 POTS patients evaluated at our autonomic center between 2018 and 2024. POTS diagnosis required documented orthostatic intolerance with a heart rate elevation of ≥30 beats per minute during the initial 10 minutes of head-up tilt table testing. Endometriosis was confirmed through surgical pathology reports where available, or via clinical documentation from a gynecology specialist. Patient-reported outcome measures were then compared between those with and without concurrent endometriosis.
resultsAmong 1,322 female POTS patients, 229 (17.3%) also carried a diagnosis of endometriosis. Those with concurrent endometriosis demonstrated greater autonomic symptom severity, evidenced by elevated Composite Autonomic Symptom Score 31 (COMPASS-31) scores across several domains. Although the prevalence of anxiety and depression did not differ significantly between groups, both cohorts exhibited substantially higher rates than the general population.
conclusionCo-occurring endometriosis was associated with heightened autonomic dysfunction across several symptom domains, indicating that endometriosis may amplify the severity of POTS-related complaints. Both POTS groups demonstrated substantially elevated rates of anxiety and depression relative to the general population, revealing a considerable mental health burden irrespective of comorbid endometriosis. These results emphasize the need for thorough autonomic symptom evaluation and routine mental health screening in patients with POTS.
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