Evidence map›Paper›PMID 42788342›Full record

ArticleInternational journal of molecular medicine2026

Sirt1 attenuates calcific aortic valve disease by inhibiting ferroptosis and enhancing mitochondrial function via the activation of the Nrf2/HO‑1/FTH1 axis.

Fei Yan, Lei Shi, Yuechan Wang, Ying Zhao, Yuanyuan Wu, Dubiao Xian, Yunheng Liang, Ning Wang, Hongwang Cui, Minni Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fei YanDepartment of Cardiac Surgery, First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570102, P.R. China.
Lei ShiDepartment of Cardiac Surgery, First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570102, P.R. China.
Yuechan WangDepartment of Cardiac Surgery, First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570102, P.R. China.
Ying ZhaoDepartment of Cardiac Surgery, First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570102, P.R. China.
Yuanyuan WuDepartment of Cardiac Surgery, First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570102, P.R. China.
Dubiao XianDepartment of Cardiac Surgery, First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570102, P.R. China.
Yunheng LiangDepartment of Cardiac Surgery, First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570102, P.R. China.
Ning WangDepartment of Cardiac Surgery, First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570102, P.R. China.
Hongwang CuiKey Laboratory of Emergency and Trauma of Ministry of Education, Haikou, Hainan 570102, P.R. China.
Minni ZhangEngineering Research Center for Hainan Biological Sample Resources of Major Diseases, Haikou, Hainan 570102, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcific aortic valve disease (CAVD) is a progressive disorder characterized by valvular calcification and currently lacks effective pharmacological therapies. Sirtuin 1 (Sirt1) has emerged as a cardioprotective factor; however, its role in CAVD remains unclear. The present study aimed to investigate whether Sirt1 attenuates CAVD by regulating iron homeostasis, ferroptosis and mitochondrial function through the nuclear factor erythroid 2‑related factor 2 (Nrf2)/heme oxygenase‑1 (HO‑1)/ferritin heavy chain 1 (FTH1) signaling axis. Sirt1 expression was evaluated in human calcified and non‑calcified aortic valves. Primary human aortic valve interstitial cells (hAVICs) were transfected with pcDNA3.1‑Sirt1 and subjected to osteogenic induction with or without the Nrf2 inhibitor, ML385, or the ferroptosis inducer, erastin. Osteogenic differentiation, mitochondrial function, ferroptosis and Nrf2/HO‑1/FTH1 signaling were analyzed.

Indexed as

Aortic ValveAortic Valve StenosisCalcinosisFerritinsFerroptosisHeme Oxygenase-1MitochondriaNF-E2-Related Factor 2Sirtuin 1AnimalsFemaleHumansMaleMembrane ProteinsMiceMice, Inbred C57BLFerritinsFTH1 protein, humanHeme Oxygenase-1Membrane ProteinsNFE2L2 protein, humanNF-E2-Related Factor 2OxidoreductasesSIRT1 protein, humanSirtuin 1calcific aortic valve diseaseferritin heavy chain 1ferroptosismitochondrial dysfunctionnuclear factor erythroid 2‑related factor 2/heme oxygenase‑1sirtuin 1

Identifiers

PMID42788342
PMCPMC13600333

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.