ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026
Optimizing MALDI-TOF MS for routine dermatophyte identification, including Trichophyton indotineae.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDermatophytosis is a common superficial fungal infection worldwide, and the recent global spread of the terbinafine-resistant fungus Trichophyton indotineae has made rapid, accurate species identification a priority for clinical laboratories. This study assessed the identification performance of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) using molecularly identified dermatophyte isolates recovered from chronic, recalcitrant, and widespread infections.
methodsA total of 134 dermatophyte isolates were analyzed, including 119 Trichophyton indotineae, 10 T. rubrum, 3 T. tonsurans, and 2 Microsporum canis. Isolates were cultured on ID Fungi Plates (IDFPs), Sabouraud glucose agar (SGA), and Kimmig agar and incubated at 27 °C for 72 h. MALDI-TOF MS analysis was performed using the VITEK
resultsIDFP achieved the highest species-level identification rate (97.8%), followed by SGA (87.3%) and Kimmig agar (75.4%). For T. indotineae, species-level identification was also highest with IDFP (97.5%), followed by SGA (88.2%) and Kimmig agar (74.8%).
conclusionsThese findings support the use of MALDI-TOF MS as a rapid and practical tool for routine dermatophyte identification and highlight the importance of optimized culture conditions for maximizing diagnostic performance. A simple, inexpensive change in laboratory workflow can therefore make routine identification of dermatophytes, including T. indotineae, reliable enough for everyday diagnostic use.
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