ArticleJournal of molecular histology2026
Effects of platelet-rich fibrin on the biological properties of rabbit adipose-derived stem cells in vitro.
Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
To investigate the effects of platelet-rich fibrin on the biological properties of rabbit adipose-derived stem cells in vitro. Rabbit adipose-derived stem cells were isolated via enzymatic digestion, characterized by flow cytometry, and their trilineage differentiation potential was confirmed. Platelet-rich fibrin was prepared from rabbit blood and characterized by scanning electron microscopy. Adipose-derived stem cells were cultured with platelet-rich fibrin, and cell proliferation and migration were assessed using CCK-8, fluorescence staining, scratch would healing, and transwell assays. Isolated adipose-derived stem cells exhibited trilineage differentiation potential. Scanning electron microscopy revealed that the platelet-rich fibrin formed a three-dimensional fibrin network with platelets entrapped within the matrix. Functionally, platelet-rich fibrin significantly enhanced adipose-derived stem cell proliferation and migration. In the proliferation assay (CCK-8), platelet-rich fibrin treatment significantly increased cell numbers from day 3 onward (P < 0.05), reaching highly significant levels at day 5 and day 7 (P < 0.01) compared to controls. Notably, the direct co-culture group showed the highest proliferative activity at day 7, significantly exceeding the indirect co-culture group (P < 0.01). In the scratch wound healing assay, platelet-rich fibrin also significantly promoted adipose-derived stem cell migration (P < 0.05), with the direct co-culture group achieving near-complete wound closure by 24 h, particularly when cells were directly embedded within the three-dimensional platelet-rich fibrin scaffold. In this in vitro setting, platelet-rich fibrin demonstrates favorable biocompatibility with rabbit adipose-derived stem cells, significantly promoting both their proliferation (time-dependently) and migration, with the three-dimensional platelet-rich fibrin scaffold providing superior support compared to soluble factors alone. These findings indicate that the platelet-rich fibrin /adipose-derived stem cell composite possesses suitable cytocompatibility properties, warranting further in vivo investigation in rabbit urethral defect models to assess its regenerative potential.
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