Evidence map›Paper›PMID 42789340›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

Targeting Oxidative and Immune Dysregulation in Wound Healing via Gold Nanoparticle Conjugate Chitosan.

Sheng-Der Hsu, Shu-Jen Chang, Cheng-An Lin, Gang-Yi Fan, Hsin-Da Tsai, Amber Lin, Juin-Hong Cherng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sheng-Der HsuDivision of Traumatology, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan (ROC).
Shu-Jen ChangDepartment and Graduate Institute of Biology and Anatomy, College of Medicine, National Defense Medical University, Taipei, Taiwan (ROC).
Cheng-An LinDepartment of Biomedical Engineering, Chung Yuan Christian University, Taoyuan, Taiwan (ROC).
Gang-Yi FanDepartment and Graduate Institute of Biology and Anatomy, College of Medicine, National Defense Medical University, Taipei, Taiwan (ROC).
Hsin-Da TsaiLaboratory of Stem Cell and Tissue Regeneration, National Defense Medical University, Taipei, Taiwan (ROC).
Amber LinLaboratory of Stem Cell and Tissue Regeneration, National Defense Medical University, Taipei, Taiwan (ROC).
Juin-Hong CherngDepartment of Biomedical Engineering, Chung Yuan Christian University, Taoyuan, Taiwan (ROC).ORCID https://orcid.org/0000-0002-7722-6134

Funding

National Defense Development Foundation 020112002National Defense Medical Affairs Bureau MND-113-0048National Defense Medical Affairs Bureau MND-114-0075National Defense Medical Affairs Bureau MND-MAB-D-112-0035National Defense Medical Affairs Bureau MND-MAB-D-114119National Defense Medical Affairs Bureau MND-MAB-D-114-159National Defense Medical University NDMU-HESP120103National Defense Medical University and Chung Yuan Christian University 111/112/113/114Tri-Service General Hospital (TSGH) TSGH_D_114127
6 · The paper itself

Abstract

A novel gold nanoparticle-chitosan (AuNP@chitosan) composite is introduced as a potent biointerface modulator for burn trauma care. In this study, the unique interfacial characteristics of the composite are linked to its therapeutic activity, and its effects on endothelial function and immune response in severe bleeding and inflammatory models are examined. AuNP@chitosan synthesis was verified using FTIR and fluorescence, and its effects were assessed in TNF-α-induced HUVECs, LPS-stimulated macrophages, and an animal model. In vitro, AuNP@chitosan protects TNF-α-injured human endothelial cells (HUVECs) by restoring thrombomodulin expression, reducing ROS, and relieving the upregulated hypoxia-adaptive markers (HIF-1α and fibronectin). Concurrently, in LPS-stimulated RAW 264.7 macrophages, it suppresses pro-inflammatory mediators (TNF-α and IL-6) while preserving COX-1 and enhancing IL-10 production. These cell-specific responses reflect distinct but complementary mechanisms, vascular protection and immune regulation, which were further validated in a rat burn model. In vivo application of AuNP@chitosan dressings significantly reduced infiltration of CD4

Indexed as

ChitosanGoldMetal NanoparticlesOxidative StressWound HealingAnimalsBurnsHumansHuman Umbilical Vein Endothelial CellsMacrophagesMaleMiceRatsRats, Sprague-DawleyRAW 264.7 CellsReactive Oxygen SpeciesChitosanGoldReactive Oxygen Speciesburn traumachitosangold nanoparticlesimmune modulationoxidative stress

Identifiers

PMID42789340
PMCPMC13614479

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.