Evidence map›Paper›PMID 42789376›Full record

ArticleExperimental physiology2026

Somatosensory processing in long COVID fatigue and its relations with physiological and psychological factors.

Bethan Thomas, Rachael Pattinson, Geoffrey Cunningham, Christine Bundy, Jennifer L Davies

Abstract read
In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bethan ThomasSchool of Healthcare Sciences, Cardiff University, Cardiff, UK.ORCID https://orcid.org/0009-0002-0294-6839
Rachael PattinsonSchool of Dentistry, Cardiff University, Cardiff, UK.ORCID https://orcid.org/0000-0002-3145-3710
Geoffrey CunninghamSchool of Healthcare Sciences, Cardiff University, Cardiff, UK.
Christine BundySchool of Healthcare Sciences, Cardiff University, Cardiff, UK.
Jennifer L DaviesSchool of Healthcare Sciences, Cardiff University, Cardiff, UK.ORCID https://orcid.org/0000-0001-7635-4815

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to quantify somatosensory processing in long COVID and interactions between somatosensory processing, fatigability, fatigue, autonomic function, mood and illness beliefs. Eighty-eight participants (44 long COVID and 44 controls) were invited to complete two testing sessions, where fatigue was induced by either a cognitive or a physical task in a cross-over design; all participants completed at least one session. Baseline questionnaires assessed trait fatigue, autonomic symptoms, mood and illness beliefs. Pre- and post-task measures included somatosensory processing, state fatigue, perceived effort and heart rate variability (HRV). Group differences and task-related changes were analysed using multivariate and linear mixed models. There was no multivariate group effect on baseline somatosensory measures (P = 0.172), nor did they change following exertion or associate with post-exertion fatigue. Long COVID participants reported greater fatigue than controls, with 64% meeting criteria for severe fatigue. State fatigue was greater at baseline, throughout both exertion tasks (all P < 0.001), and increased more during exertion compared with controls. Despite this, cognitive and physical performance changed similarly across tasks, with no group differences in fatigability (P = 0.199-0.441). Long COVID participants had lower resting HRV, indicating autonomic dysfunction, but HRV was not associated with fatigue. Only group status (P < 0.001) and pre-task fatigue (P < 0.001) were associated with post-exertion fatigue. Within long COVID participants, greater depression (P < 0.001) and perceived illness threat (P = 0.033) were associated with greater trait fatigue. The absence of somatosensory abnormalities provides no support for the sensory attenuation model of fatigue in long COVID.

Indexed as

autonomic nervous systemfatigueillness perceptionslong COVIDmoodsomatosensory system

Identifiers

PMID42789376
PMCPMC13614499

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.