Evidence map›Paper›PMID 42789718›Full record

ArticleScience advances2026

Multimodal profiling of atherosclerosis: Protocol and pilot data for the AtherOMICS biobank.

Luka Živković, Roya Batool, Julian Louma, Paulo Vinicius Gil Alabarse, Yingle Li, Lanyue Zhang, Stefan Mayrhofer, Anushree Ray, Mohamad Ali Antabi, Panagiotis Zangas and 12 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Luka ŽivkovićInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID 0000-0002-9979-890X
Roya BatoolInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID 0009-0005-9227-7676
Julian LoumaInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID 0009-0005-1400-7152
Paulo Vinicius Gil AlabarseInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID 0000-0002-9721-9302
Yingle LiInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID 0000-0002-6454-9495
Lanyue ZhangInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
Stefan MayrhoferInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID 0009-0003-5871-7290
Anushree RayInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID 0009-0000-8890-0975
Mohamad Ali AntabiInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID 0000-0002-9903-1063
Panagiotis ZangasInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID 0009-0006-1350-4154
Jana MattarInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID 0009-0003-1752-6295
Anna KopczakInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID 0000-0002-5037-2342
Andreas SchindlerInstitute of Neuroradiology, University Hospital, LMU Munich, Munich, Germany.ORCID 0000-0003-0183-5782
Paul ReidlerDepartment of Radiology, University Hospital, LMU Munich, Munich, Germany.
Yaw AsareInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID 0000-0002-8946-5650
Steffen TiedtInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID 0000-0002-8817-8457
Lars KellertDepartment of Neurology, University Hospital, LMU Munich, Munich, Germany.
Abdalla MareiDepartment of Vascular Surgery, University Hospital, LMU Munich, Munich, Germany.ORCID 0009-0003-3237-5712
Barbara RantnerDepartment of Vascular Surgery, University Hospital, LMU Munich, Munich, Germany.
Martin DichgansInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID 0000-0002-0654-387X
Nikolaos TsilimparisDepartment of Vascular Surgery, University Hospital, LMU Munich, Munich, Germany.ORCID 0000-0002-6313-7595
Marios K GeorgakisInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID 0000-0003-3507-3659

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Omics technologies enable deep profiling of human atherosclerosis but have mostly been applied in small studies lacking integration with other data modalities. AtherOMICS is a biobanking project linking multiomic atherosclerotic plaque phenotyping with blood biobanking, in vivo imaging, and clinical data. Here, we present the study protocol and show pilot results that demonstrate technical feasibility. Since August 2022, 246 patients scheduled to undergo carotid or femoral endarterectomy at Ludwig-Maximilians-Universität Klinikum (Munich, Germany), have been enrolled (median age, 73 years; 32% female), with recruitment ongoing. Plaques undergo systematic histological characterization of lipid core, calcification, intraplaque hemorrhage, fibrous cap, macrophages, and smooth muscle cells. Single-nucleus RNA sequencing (

Indexed as

AtherosclerosisBiological Specimen BanksPlaque, AtheroscleroticAgedBiomarkersFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMultimodal ImagingMultiomicsPilot ProjectsProteomicsBiomarkers

Identifiers

PMID42789718
PMCPMC13614409

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.