Evidence map›Paper›PMID 42792176›Full record

ReviewAntioxidants (Basel, Switzerland)2026

Molecular Hydrogen and the Uremic Skeleton: A Critical Review and Turnover-State-Dependent Redox Hypothesis in CKD-MBD.

Po-Jen Hsiao, Ching-Tsai Hsu, Wen-Fang Chiang, Jenq-Shyong Chan, Li-Yen Huang, Chung-Chi Yang, Kuo-Cheng Lu

Abstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Po-Jen HsiaoDivision of Nephrology, Department of Internal Medicine, Taoyuan Armed Forces General Hospital, Taoyuan 325208, Taiwan.
Ching-Tsai HsuDivision of Cardiovascular Medicine, Taoyuan Armed Forces General Hospital, Taoyuan 325208, Taiwan.
Wen-Fang ChiangDivision of Nephrology, Department of Internal Medicine, Taoyuan Armed Forces General Hospital, Taoyuan 325208, Taiwan.
Jenq-Shyong ChanDivision of Nephrology, Department of Internal Medicine, Taoyuan Armed Forces General Hospital, Taoyuan 325208, Taiwan.ORCID 0000-0003-2791-0162
Li-Yen HuangDivision of Cardiovascular Medicine, Taoyuan Armed Forces General Hospital, Taoyuan 325208, Taiwan.
Chung-Chi YangDivision of Cardiovascular Medicine, Taoyuan Armed Forces General Hospital, Taoyuan 325208, Taiwan.
Kuo-Cheng LuDivision of Nephrology, Department of Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23143, Taiwan.

Funding

Taoyuan Armed Forces General Hospital TYAFGH-D-115024
6 · The paper itself

Abstract

Chronic kidney disease-mineral and bone disorder (CKD-MBD) confers a substantial fracture burden that is only partly addressed by therapies targeting phosphate, parathyroid hormone, and vitamin D. Redox dysregulation may represent a complementary mechanism: reactive oxygen species (ROS) are required for receptor activator of nuclear factor-κB ligand (RANKL)-dependent osteoclastogenesis, whereas excessive ROS impair Wnt/β-catenin signalling in osteoblast precursors and promote osteocyte dysfunction. Uremic toxins, inflammation, and dialysis further increase oxidative stress. Molecular hydrogen (H

Indexed as

CKD-MBDmolecular hydrogenosteoblastosteoclastredox signalling

Identifiers

PMID42792176
PMCPMC13603868

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.