ArticleAntioxidants (Basel, Switzerland)2026
Fungal-Derived Decahydrofluorene Alkaloids Promote Mitochondrial Resilience and Neuroprotection in Cellular and Animal Models of Parkinson's Disease.
Alberto Vázquez-Jiménez, Margarita M Marques, José M Sánchez, Jesús Agulla, Rebeca Lapresa, Mónica Trigal-Martínez, Rosalía Fernández-Alonso, Gracia Merino, Antonio Fernández, Antonella Consiglio and 4 more
Abstract read
In one paragraphArticle in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Alberto Vázquez-JiménezInstituto de Biomedicina and Departamento de Biología Molecular, Universidad de León, 24071 León, Spain.
Jesús AgullaInstituto de Biología Funcional y Genómica, Universidad de Salamanca, Consejo Superior de Investigaciones Científicas (CSIC), 37007 Salamanca, Spain.ORCID 0000-0001-9574-2549 Rebeca LapresaInstituto de Biología Funcional y Genómica, Universidad de Salamanca, Consejo Superior de Investigaciones Científicas (CSIC), 37007 Salamanca, Spain.ORCID 0000-0001-8901-3972 Mónica Trigal-MartínezBiomar Microbial Technologies, Parque Tecnológico de León, 24009 León, Spain.
Rosalía Fernández-AlonsoInstituto de Biomedicina and Departamento de Biología Molecular, Universidad de León, 24071 León, Spain.
Gracia MerinoInstituto de Desarrollo Ganadero y Sanidad Animal, Universidad de León, 24071 León, Spain.ORCID 0000-0002-7620-3475 Antonio FernándezBiomar Microbial Technologies, Parque Tecnológico de León, 24009 León, Spain.
Antonella ConsiglioDepartament de Patologia i Terapèutica Experimental, Hospital Universitario de Bellvitge-(IDIBELL), 08908 L'Hospitalet de Llobregat, Spain.ORCID 0000-0002-3988-6254 Juan P BolañosInstituto de Biología Funcional y Genómica, Universidad de Salamanca, Consejo Superior de Investigaciones Científicas (CSIC), 37007 Salamanca, Spain.
Ángeles AlmeidaInstituto de Biología Funcional y Genómica, Universidad de Salamanca, Consejo Superior de Investigaciones Científicas (CSIC), 37007 Salamanca, Spain.ORCID 0000-0003-0485-8904 María C MarínInstituto de Biomedicina and Departamento de Biología Molecular, Universidad de León, 24071 León, Spain.ORCID 0000-0002-7149-287X Lorena López-FerrerasInstituto de Biomedicina and Departamento de Biología Molecular, Universidad de León, 24071 León, Spain.ORCID 0000-0002-5455-475X Funding
Biomar Microbial Technologies (Spain) Art83_NAPAConsejería de Educación de la Junta de Castilla y LeónInstitute of Health Carlos III CB16/10/00282Institute of Health Carlos III PI24/00810Institute of Health Carlos III RD24/0009/0005Junta of Castile and León LE033P24Junta of Castile and León LE052P23Spanish State Research Agency PID2022-138813OB-I00Universidad de León
6 · The paper itselfAbstract
Parkinson's disease (PD) is characterized by oxidative stress, mitochondrial dysfunction, and dopaminergic neuron loss, for which effective treatments remain unavailable. Here, we report CL0179, a fungal-derived decahydrofluorene alkaloid with antioxidant-associated neuroprotective properties, and evaluate its effects across cellular and animal PD models. CL0179 exhibited a favorable safety profile and protected SHSY5Y against 6-hydroxydopamine- (6-OHDA), rotenone-, and 1-Methyl-4-phenylpyridinium-iodide (MPP
Indexed as
6-OHDAantioxidantmitochondrial networkmitochondrial resilienceMPP+neurodegenerative diseaseneuroprotectionParkinson’s disease
Identifiers
PMID42792190
PMCPMC13603763
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