Evidence map›Paper›PMID 42792221›Full record

ArticleAntioxidants (Basel, Switzerland)2026

PCSK9 Inhibition Attenuates Renal Oxidative Stress and Lipotoxicity in Diabetic Kidney Disease in Association with AMPK Activation.

Keum-Jin Yang, Sunha Lee, Sungmi Kim, Sojung Youn, Hwajin Park, Yunkyeong Hwang, Suyeon Han, Yoon-Kyung Chang, Cheol Whee Park, Yu Ah Hong

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Keum-Jin YangClinical Research Institute, Daejeon St. Mary's Hospital, Daejeon 34943, Republic of Korea.
Sunha LeeClinical Research Institute, Daejeon St. Mary's Hospital, Daejeon 34943, Republic of Korea.
Sungmi KimDivision of Nephrology, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Sojung YounDivision of Nephrology, Department of Internal Medicine, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Hwajin ParkDivision of Nephrology, Department of Internal Medicine, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Yunkyeong HwangDivision of Nephrology, Department of Internal Medicine, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Suyeon HanDivision of Nephrology, Department of Internal Medicine, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Yoon-Kyung ChangDivision of Nephrology, Department of Internal Medicine, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.ORCID 0000-0003-4193-2034
Cheol Whee ParkDivision of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Yu Ah HongDivision of Nephrology, Department of Internal Medicine, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.ORCID 0000-0001-7856-4955

Funding

Clinical Research Institute of Daejeon St. Mary's Hospital CMCDJ-P-2022-020, CMCDJ-P-2025-010National Research Foundation of Korea RS-2021-NR061667, RS-2026-25490093
6 · The paper itself

Abstract

Renal lipotoxicity and oxidative stress are major contributors to diabetic kidney disease (DKD), but the role of proprotein convertase subtilisin/kexin type 9 (PCSK9) and its relationship with AMP-activated protein kinase (AMPK) signaling remain unclear. We investigated the effects of PCSK9 inhibition on renal lipotoxicity and oxidative stress in

Indexed as

AMP-activated protein kinaseapoptosisdiabetic nephropathiesoxidative stressproprotein convertase subtilisin/kexin type 9

Identifiers

PMID42792221
PMCPMC13603972

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.